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- Sakakura, S., E. Inagaki, Y. Ochiai, M. Yamamoto, N. Takai, T. Nagata, K. Higa, Y. Sato, H. Toshida, D. Murat, M. Hirayama, Y. Ogawa, K. Negishi and S. Shimmura (2023). “A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model.” Int J Mol Sci 24(22).
- Altshuler, A., A. Amitai-Lange, W. Nasser, S. Dimri, S. Bhattacharya, B. Tiosano, R. Barbara, D. Aberdam, S. Shimmura and R. Shalom-Feuerstein (2023). “Eyes open on stem cells.” Stem Cell Reports.
- Sakakura, S., E. Inagaki, T. Sayano, R. Yamazaki, N. Fusaki, S. Hatou, M. Hirayama, K. Tsubota, K. Negishi, H. Okano and S. Shimmura (2023). “Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy.” Regen Ther 24: 592-60
- Terai, H., M. Ishii, R. Takemura, H. Namkoong, K. Shimamoto, K. Masaki, T. Tanosaki, S. Chubachi, E. Matsuyama, R. Hayashi, T. Shimada, L. Shigematsu, F. Ito, M. Kaji, H. Takaoka, M. Kurihara, K. Nakagawara, S. Tomiyasu, K. Sasahara, A. Saito, S. Otake, S. Azekawa, M. Okada, T. Fukushima, A. Morita, H. Tanaka, K. Sunata, M. Asaoka, M. Nishie, T. Shinozaki, T. Ebisudani, Y. Akiyama, A. Mitsuishi, S. Nakayama, T. Ogawa, K. Sakurai, M. Irie, K. Yagi, K. Ohgino, J. Miyata, H. Kabata, S. Ikemura, H. Kamata, H. Yasuda, I. Kawada, R. Kimura, M. Kondo, T. Iwasaki, N. Ishida, G. Hiruma, N. Miyazaki, Y. Ishibashi, S. Harada, T. Fujita, D. Ito, S. Bun, H. Tabuchi, S. Kanzaki, E. Shimizu, K. Fukuda, J. Yamagami, K. Kobayashi, T. Hirano, T. Inoue, M. Haraguchi, J. Kagyo, T. Shiomi, H. Lee, K. Sugihara, N. Omori, K. Sayama, K. Otsuka, N. Miyao, T. Odani, M. Watase, T. Mochimaru, R. Satomi, Y. Oyamada, K. Masuzawa, T. Asakura, S. Nakayama, Y. Suzuki, R. Baba, S. Okamori, D. Arai, I. Nakachi, N. Kuwahara, A. Fujiwara, T. Oakada, T. Ishiguro, T. Isosno, Y. Makino, S. Mashimo, T. Kaido, N. Minematsu, S. Ueda, K. Minami, R. Hagiwara, T. Manabe, T. Fukui, Y. Funatsu, H. Koh, T. Yoshiyama, H. Kokuto, T. Kusumoto, A. Oashi, M. Miyawaki, F. Saito, T. Tani, K. Ishioka, S. Takahashi, M. Nakamura, N. Harada, H. Sasano, A. Goto, Y. Kusaka, T. Ohba, Y. Nakano, K. Nishio, Y. Nakajima, S. Suzuki, S. Yoshida, H. Tateno, N. Kodama, M. Shunsuke, S. Sakamoto, M. Okamoto, Y. Nagasaki, A. Umeda, K. Miyagawa, H. Shimada, K. Hagimura, K. Nagashima, T. Sato, Y. Sato, N. Hasegawa, T. Takebayashi, J. Nakahara, M. Mimura, K. Ogawa, S. Shimmura, K. Negishi, K. Tsubota, M. Amagai, R. Goto, Y. Ibuka, Y. Kitagawa, T. Kanai and K. Fukunaga (2023). “Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study.” Respir Investig 61(6): 802-814.
- Shimizu, E., S. Sato, K. Asai, Y. Ogawa, S. Shimmura and K. Negishi (2023). “Clinical Features of Sjogren Syndrome-Related Dry Eye Disease in Anterior Segment Photographs.” Cornea.
- Hatou, S. and S. Shimmura (2023). “Advances in corneal regenerative medicine with iPS cells.” Jpn J Ophthalmol 67(5): 541-545.
- Matsumae, H., T. Yamaguchi, Y. Kusano, S. Shimmura, A. Kobayashi, Y. Morizane and J. Shimazaki (2022). “Graft Size and Double Scroll Formation Rate in Descemet Membrane Endothelial Keratoplasty.” Curr Eye Res 47(9): 1246-1251.
- Inagaki, E., E. Arai, S. Hatou, T. Sayano, H. Taniguchi, K. Negishi, Y. Kanai, Y. Sato, H. Okano, K. Tsubota and S. Shimmura (2022). “The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.” Stem Cells Transl Med 11(8): 841-849.
- Shimizu, S., S. Sato, H. Taniguchi, E. Shimizu, J. He, S. Hayashi, K. Negishi, Y. Ogawa and S. Shimmura (2021). “Observation of Chronic Graft-Versus-Host Disease Mouse Model Cornea with In Vivo Confocal Microscopy.” Diagnostics (Basel) 11(8).
- Rusch, R. M., Y. Ogawa, S. Sato, S. Morikawa, E. Inagaki, E. Shimizu, K. Tsubota and S. Shimmura (2021). “MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation.” Int J Mol Sci 22(9).
- Nakagawara, K., H. Namkoong, H. Terai, K. Masaki, T. Tanosaki, K. Shimamoto, H. Lee, H. Tanaka, S. Okamori, H. Kabata, S. Chubachi, S. Ikemura, H. Kamata, H. Yasuda, I. Kawada, M. Ishii, Y. Ishibashi, S. Harada, T. Fujita, D. Ito, S. Bun, H. Tabuchi, S. Kanzaki, E. Shimizu, K. Fukuda, J. Yamagami, K. Kobayashi, T. Hirano, T. Inoue, J. Kagyo, T. Shiomi, K. Ohgino, K. Sayama, K. Otsuka, N. Miyao, T. Odani, Y. Oyamada, K. Masuzawa, S. Nakayama, Y. Suzuki, R. Baba, I. Nakachi, N. Kuwahara, T. Ishiguro, S. Mashimo, N. Minematsu, S. Ueda, T. Manabe, Y. Funatsu, H. Koh, T. Yoshiyama, F. Saito, K. Ishioka, S. Takahashi, M. Nakamura, A. Goto, N. Harada, Y. Kusaka, Y. Nakano, K. Nishio, H. Tateno, R. Edahiro, Y. Takeda, A. Kumanogoh, N. Kodama, M. Okamoto, A. Umeda, K. Hagimura, T. Sato, N. Miyazaki, R. Takemura, Y. Sato, T. Takebayashi, J. Nakahara, M. Mimura, K. Ogawa, S. Shimmura, K. Negishi, K. Tsubota, M. Amagai, R. Goto, Y. Ibuka, N. Hasegawa, Y. Kitagawa, T. Kanai and K. Fukunaga (2021). “Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol.” BMJ Open Respir Res 8(1).
- Hatou, S., T. Sayano, K. Higa, E. Inagaki, Y. Okano, Y. Sato, H. Okano, K. Tsubota and S. Shimmura (2021). “Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model.” Stem Cell Res 55: 102497.
- Hata-Mizuno, M., Y. Uchino, M. Uchino, S. Shimmura, Y. Ogawa, K. Tsubota and K. Negishi (2021). “Analysis of the Association between Galectin-3 Concentration in Tears and the Severity of Dry Eye Disease: A Case-Control Study.” J Clin Med 11(1).
- Yamazaki, R., R. Nejima, Y. Ichihashi, K. Miyata, K. Tsubota and S. Shimmura (2020). “Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy.” Jpn J Ophthalmol 64(6): 585-590.
- Yamane, M., S. Sato, E. Shimizu, S. Shibata, M. Hayano, T. Yaguchi, H. Kamijuku, M. Ogawa, T. Suzuki, S. Mukai, S. Shimmura, H. Okano, T. Takeuchi, Y. Kawakami, Y. Ogawa and K. Tsubota (2020). “Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.” FASEB J 34(8): 10778-10800.
- Higa, K., J. Higuchi, R. Kimoto, H. Miyashita, J. Shimazaki, K. Tsubota and S. Shimmura (2020). “Human corneal limbal organoids maintaining limbal stem cell niche function.” Stem Cell Res 49: 102012.
- Hata-Mizuno, M., E. Ingaki, H. Mitamura, Y. Uchino, K. Tsubota and S. Shimmura (2020). “Conjunctival Epithelial Ingrowth After Penetrating Keratoplasty.” Cornea 39(9): 1181-1183.
- Yamashita, K., S. Hatou, Y. Uchino, K. Tsubota and S. Shimmura (2019). “Prognosis after lamellar keratoplasty for limbal dermoids using preserved corneas.” Jpn J Ophthalmol 63(1): 56-64.
- Venkatraman, A., G. Hochart, D. Bonnel, J. Stauber, S. Shimmura, L. Rajamani, K. Pervushin and J. S. Mehta (2019). “Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI-H626R and TGFBI-R124C Mutations.” Proteomics Clin Appl 13(1): e1800053.
- Fujii, S., S. Yoshida, E. Inagaki, S. Hatou, K. Tsubota, M. Takahashi, S. Shimmura and S. Sugita (2019). “Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells.” Stem Cells Dev 28(1): 28-43.
- Deng, S. X., V. Borderie, C. C. Chan, R. Dana, F. C. Figueiredo, J. A. P. Gomes, G. Pellegrini, S. Shimmura, F. E. Kruse and G. and The International Limbal Stem Cell Deficiency Working (2019). “Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency.” Cornea 38(3): 364-375.
- Yamashita, K., E. Inagaki, S. Hatou, K. Higa, A. Ogawa, H. Miyashita, K. Tsubota and S. Shimmura (2018). “Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord.” Stem Cells Dev 27(16): 1097-1108.
- Yamashita, K., S. Hatou, E. Inagaki, K. Higa, K. Tsubota and S. Shimmura (2018). “A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells.” Sci Rep 8(1): 16868.
- Yamane, M., Y. Ogawa, S. Mukai, S. Yaguchi, H. Kamijuku, T. Inaba, K. Asai, S. Morikawa, Y. Kawakami, S. Shimmura and K. Tsubota (2018). “Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease.” Cornea 37(1): 102-108.
- Den, S., S. Shimmura and J. Shimazaki (2018). “Cataract surgery after deep anterior lamellar keratoplasty and penetrating keratoplasty in age- and disease-matched eyes.” J Cataract Refract Surg 44(4): 496-503.
- Yamazaki, R., K. Yamazoe, S. Yoshida, S. Hatou, E. Inagaki, H. Okano, K. Tsubota and S. Shimmura (2017). “The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model.” Sci Rep 7(1): 15584.
- Shimmura-Tomita, M., S. Shimmura, K. Tsubota and J. Shimazaki (2017). “Penetrating Keratoplasty Performed by Residents Compared With an Experienced Cornea Transplant Surgeon.” J Surg Educ 74(2): 258-263.
- Miyashita, H., H. Niwano, S. Yoshida, S. Hatou, E. Inagaki, K. Tsubota and S. Shimmura (2017). “Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model.” Sci Rep 7: 43557.
- Inagaki, E., S. Hatou, K. Higa, S. Yoshida, S. Shibata, H. Okano, K. Tsubota and S. Shimmura (2017). “Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration.” Stem Cells Transl Med 6(3): 788-798.
- Hirayama, M., S. B. H. Ko, T. Kawakita, T. Akiyama, S. K. Goparaju, A. Soma, Y. Nakatake, M. Sakota, N. Chikazawa-Nohtomi, S. Shimmura, K. Tsubota and M. S. H. Ko (2017). “Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells.” NPJ Aging Mech Dis 3: 1.
- Ogawa, Y., S. Morikawa, H. Okano, Y. Mabuchi, S. Suzuki, T. Yaguchi, Y. Sato, S. Mukai, S. Yaguchi, T. Inaba, S. Okamoto, Y. Kawakami, K. Tsubota, Y. Matsuzaki and S. Shimmura (2016). “MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.” Elife 5: e09394.
- Ogawa, A., Y. Matsumoto, T. Yaguchi, S. Shimmura and K. Tsubota (2016). “Successful treatment of Beauveria bassiana fungal keratitis with topical voriconazole.” J Infect Chemother 22(4): 257-260.
- Ishiyama, S., Y. Mori, R. Nejima, T. Tokudome, S. Shimmura, K. Miyata and S. Amano (2016). “Comparison of Long-Term Outcomes of Visual Function and Endothelial Cell Survival After Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty Using Mixed-Effects Models.” Cornea.
- Hirayama, M., Y. Liu, T. Kawakita, S. Shimmura and K. Tsubota (2016). “Cytokeratin expression in mouse lacrimal gland germ epithelium.” Exp Eye Res 146: 54-59.
- Yamazoe, K., S. Yoshida, M. Yasuda, S. Hatou, E. Inagaki, Y. Ogawa, K. Tsubota and S. Shimmura (2015). “Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2.” PLoS One 10(7): e0133397.
- Yaguchi, S., Y. Ogawa, T. Kawakita, S. Shimmura and K. Tsubota (2015). “Tissue Renin-Angiotensin System in Lacrimal Gland Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease.” Cornea 34 Suppl 11: S142-152.
- Kawakita, T., S. Shimmura and K. Tsubota (2015). “Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjogren Syndrome.” Asia Pac J Ophthalmol (Phila) 4(2): 101-105.
- Kamoshita, M., Y. Matsumoto, K. Nishimura, Y. Katono, M. Murata, Y. Ozawa, S. Shimmura and K. Tsubota (2015). “Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin.” J Infect Chemother 21(2): 141-143.
- Fukui, M., Y. Ogawa, S. Shimmura, S. Hatou, Y. Ichihashi, S. Yaguchi, M. Hirayama, T. Kawakita and K. Tsubota (2015). “Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz’s disease.” Mod Rheumatol: 1-7.
- Yoshida, T., Y. Ozawa, K. Suzuki, K. Yuki, M. Ohyama, W. Akamatsu, Y. Matsuzaki, S. Shimmura, K. Mitani, K. Tsubota and H. Okano (2014). “The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.” Mol Brain 7: 45.
- Shiba, D., S. Hatou, T. Ono, S. Hosoda, S. Tanabe, N. Ozeki, K. Yuki, M. Shimoyama, K. Fukagawa, S. Shimmura and K. Tsubota (2014). “Multivariable logistic regression model: a novel mathematical model that predicts visual field sensitivity from macular ganglion cell complex thickness in glaucoma.” PLoS One 9(8): e104126.
- Satake, Y., T. Yamaguchi, M. Hirayama, K. Higa, S. Shimazaki-Den, M. Dogru, T. Kawakita, M. Kawashima, S. Shimmura, K. Tsubota and J. Shimazaki (2014). “Ocular surface reconstruction by cultivated epithelial sheet transplantation.” Cornea 33 Suppl 11: S42-46.
- Kamoshita, M., Y. Ozawa, S. Kubota, S. Miyake, C. Tsuda, N. Nagai, K. Yuki, S. Shimmura, K. Umezawa and K. Tsubota (2014). “AMPK-NF-kappaB axis in the photoreceptor disorder during retinal inflammation.” PLoS One 9(7): e103013.
- Fujii, S., Y. Matsumoto, M. Fukui, J. Fujitake, T. Kawakita, S. Shimmura and K. Tsubota (2014). “Clinical backgrounds of postoperative keratoplasty patients with spontaneous wound dehiscence or gaps after suture removal.” Cornea 33(12): 1320-1323.
- Yaguchi, S., Y. Ogawa, S. Shimmura, T. Kawakita, S. Hatou, S. Satofuka, S. Nakamura, T. Imada, H. Miyashita, S. Yoshida, T. Yaguchi, Y. Ozawa, T. Mori, S. Okamoto, Y. Kawakami, S. Ishida and K. Tsubota (2013). “Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease.” PLoS One 8(6): e64724.
- Narimatsu, T., Y. Ozawa, S. Miyake, S. Kubota, M. Hirasawa, N. Nagai, S. Shimmura and K. Tsubota (2013). “Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice.” Invest Ophthalmol Vis Sci 54(7): 4555-4562.
- Miyashita, H., S. Yokoo, S. Yoshida, T. Kawakita, S. Yamagami, K. Tsubota and S. Shimmura (2013). “Long-term maintenance of limbal epithelial progenitor cells using rho kinase inhibitor and keratinocyte growth factor.” Stem Cells Transl Med 2(10): 758-765.
- Konomi, K., Y. Satake, S. Shimmura, K. Tsubota and J. Shimazaki (2013). “Long-term results of amniotic membrane transplantation for partial limbal deficiency.” Cornea 32(8): 1110-1115.
- Kawakita, T., F. Kawabata, T. Tsuji, M. Kawashima, S. Shimmura and K. Tsubota (2013). “Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial.” Biomed Res 34(5): 215-220.
- Kawai, M., Y. Ogawa, S. Shimmura, S. Ohta, T. Suzuki, N. Kawamura, M. Kuwana, Y. Kawakami and K. Tsubota (2013). “Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease.” Sci Rep 3: 2455.
- Inagaki, E., S. Hatou, S. Yoshida, H. Miyashita, K. Tsubota and S. Shimmura (2013). “Expression and distribution of claudin subtypes in human corneal endothelium.” Invest Ophthalmol Vis Sci 54(12): 7258-7265.
- Hirayama, M., M. Ogawa, M. Oshima, Y. Sekine, K. Ishida, K. Yamashita, K. Ikeda, S. Shimmura, T. Kawakita, K. Tsubota and T. Tsuji (2013). “Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ.” Nat Commun 4: 2497.
- Higa, K., N. Kato, S. Yoshida, Y. Ogawa, J. Shimazaki, K. Tsubota and S. Shimmura (2013). “Aquaporin 1-positive stromal niche-like cells directly interact with N-cadherin-positive clusters in the basal limbal epithelium.” Stem Cell Res 10(2): 147-155.
- Hatou, S., S. Yoshida, K. Higa, H. Miyashita, E. Inagaki, H. Okano, K. Tsubota and S. Shimmura (2013). “Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/beta-catenin signaling.” Stem Cells Dev 22(5): 828-839.
- Hatou, S., K. Higa, E. Inagaki, S. Yoshida, E. Kimura, R. Hayashi, M. Tsujikawa, K. Tsubota, K. Nishida and S. Shimmura (2013). “Validation of Na,K-ATPase pump function of corneal endothelial cells for corneal regenerative medicine.” Tissue Eng Part C Methods 19(12): 901-910.
- Yaguchi, S., Y. Ogawa, S. Shimmura, S. Hatou, S. Nakamura, T. Inaba, T. Imada, Y. Ozawa, Y. Kawakami, S. Ishida and K. Tsubota (2012). “Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland.” Invest Ophthalmol Vis Sci 53(9): 5416-5425.
- Uchino, Y., T. Kawakita, M. Miyazawa, T. Ishii, H. Onouchi, K. Yasuda, Y. Ogawa, S. Shimmura, N. Ishii and K. Tsubota (2012). “Oxidative stress induced inflammation initiates functional decline of tear production.” PLoS One 7(10): e45805.
- Tatematsu, Y., Y. Ogawa, S. Shimmura, M. Dogru, S. Yaguchi, T. Nagai, K. Yamazaki, K. Kameyama, S. Okamoto, Y. Kawakami and K. Tsubota (2012). “Mucosal microvilli in dry eye patients with chronic GVHD.” Bone Marrow Transplant 47(3): 416-425.
- Ozeki, N., K. Yuki, D. Shiba, S. Shimmura, D. Murat and K. Tsubota (2012). “Intraocular pressure elevation after Descemet’s stripping endothelial keratoplasty.” Jpn J Ophthalmol 56(4): 307-311.
- Omoto, M., S. Yoshida, H. Miyashita, T. Kawakita, K. Yoshida, A. Kishino, T. Kimura, S. Shibata, K. Tsubota, H. Okano and S. Shimmura (2012). “The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model.” PLoS One 7(11): e47716.
- Kobayashi, S., T. Kawakita, M. Kawashima, N. Okada, K. Mishima, I. Saito, M. Ito, S. Shimmura and K. Tsubota (2012). “Characterization of cultivated murine lacrimal gland epithelial cells.” Mol Vis 18: 1271-1277.
- Kawashima, M., T. Kawakita, T. Inaba, N. Okada, M. Ito, S. Shimmura, M. Watanabe, K. Shinmura and K. Tsubota (2012). “Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice.” PLoS One 7(3): e33148.
- Kamoi, M., Y. Ogawa, S. Nakamura, M. Dogru, T. Nagai, H. Obata, M. Ito, M. Kaido, T. Kawakita, Y. Okada, Y. Kawakami, S. Shimmura and K. Tsubota (2012). “Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren’s type dry eye in visual display terminal users.” PLoS One 7(9): e43688.
- Yoshida, S., M. Yasuda, H. Miyashita, Y. Ogawa, T. Yoshida, Y. Matsuzaki, K. Tsubota, H. Okano and S. Shimmura (2011). “Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells.” PLoS One 6(12): e28856.
- Uchino, Y., S. Shimmura, T. Yamaguchi, T. Kawakita, Y. Matsumoto, K. Negishi and K. Tsubota (2011). “Comparison of corneal thickness and haze in DSAEK and penetrating keratoplasty.” Cornea 30(3): 287-290.
- Shimazaki, J., S. Den, M. Omoto, Y. Satake, S. Shimmura and K. Tsubota (2011). “Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation.” Am J Ophthalmol 152(1): 33-39 e31.
- Okada, N., T. Kawakita, K. Mishima, I. Saito, H. Miyashita, S. Yoshida, S. Shimmura and K. Tsubota (2011). “Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro.” Invest Ophthalmol Vis Sci 52(6): 2905-2910.
- Niibe, K., Y. Kawamura, D. Araki, S. Morikawa, K. Miura, S. Suzuki, S. Shimmura, T. Sunabori, Y. Mabuchi, Y. Nagai, T. Nakagawa, H. Okano and Y. Matsuzaki (2011). “Purified mesenchymal stem cells are an efficient source for iPS cell induction.” PLoS One 6(3): e17610.
- Kubota, M., S. Shimmura, S. Kubota, H. Miyashita, N. Kato, K. Noda, Y. Ozawa, T. Usui, S. Ishida, K. Umezawa, T. Kurihara and K. Tsubota (2011). “Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.” Invest Ophthalmol Vis Sci 52(1): 427-433.
- Kawashima, M., T. Kawakita, Y. Maida, M. Kamoi, Y. Ogawa, S. Shimmura, K. Masutomi and K. Tsubota (2011). “Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients.” Mol Vis 17: 1397-1404.
- Kawakita, T., K. Higa, S. Shimmura, M. Tomita, K. Tsubota and J. Shimazaki (2011). “Fate of corneal epithelial cells separated from limbus in vivo.” Invest Ophthalmol Vis Sci 52(11): 8132-8137.
- Inagaki, E., Y. Ogawa, Y. Matsumoto, T. Kawakita, S. Shimmura and K. Tsubota (2011). “Four cases of corneal perforation in patients with chronic graft-versus-host disease.” Mol Vis 17: 598-606.
- Higa, K., N. Takeshima, F. Moro, T. Kawakita, M. Kawashima, M. Demura, J. Shimazaki, T. Asakura, K. Tsubota and S. Shimmura (2011). “Porous Silk Fibroin Film as a Transparent Carrier for Cultivated Corneal Epithelial Sheets.” J Biomater Sci 22: 2261-2276.
- Hatou, S., S. Shimmura, J. Shimazaki, T. Usui, S. Amano, H. Yokogawa, A. Kobayashi, X. Zheng, A. Shiraishi, Y. Ohashi, T. Inatomi and K. Tsubota (2011). “Mathematical projection model of visual loss due to fuchs corneal dystrophy.” Invest Ophthalmol Vis Sci 52(11): 7888-7893.
- Hatou, S., M. Dogru, O. M. Ibrahim, T. Wakamatsu, E. A. Sato, S. Shimmura, K. Negishi and K. Tsubota (2011). “The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in Mooren’s ulcer.” Invest Ophthalmol Vis Sci 52(9): 6680-6689.
- Yamaguchi, T., K. Negishi, K. Yamaguchi, M. Dogru, Y. Uchino, S. Shimmura and K. Tsubota (2010). “Comparison of anterior and posterior corneal surface irregularity in Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty.” Cornea 29(10): 1086-1090.
- Omoto, M., S. Shimmura, S. Hatou, Y. Ichihashi, T. Kawakita and K. Tsubota (2010). “Simultaneous deep anterior lamellar keratoplasty and limbal allograft in bilateral limbal stem cell deficiency.” Jpn J Ophthalmol 54(6): 537-543.
- Kubota, M., S. Shimmura, H. Miyashita, M. Kawashima, T. Kawakita and K. Tsubota (2010). “The anti-oxidative role of ABCG2 in corneal epithelial cells.” Invest Ophthalmol Vis Sci 51(11): 5617-5622.
- Kawashima, M., T. Kawakita, N. Okada, Y. Ogawa, D. Murat, S. Nakamura, H. Nakashima, S. Shimmura, K. Shinmura and K. Tsubota (2010). “Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats.” Biochem Biophys Res Commun 397(4): 724-728.
- Yuki, K., S. Shimmura, D. Shiba and K. Tsubota (2009). “End-stage glaucoma in Stevens-Johnson syndrome.” Jpn J Ophthalmol 53(1): 68-70.
- Yamaguchi, T., K. Negishi, K. Yamaguchi, D. Murat, Y. Uchino, S. Shimmura and K. Tsubota (2009). “Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty.” J Cataract Refract Surg 35(4): 688-694.
- Omoto, M., H. Miyashita, S. Shimmura, K. Higa, T. Kawakita, S. Yoshida, M. McGrogan, J. Shimazaki and K. Tsubota (2009). “The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets.” Invest Ophthalmol Vis Sci 50(5): 2109-2115.
- Ogawa, Y., S. Shimmura, T. Kawakita, S. Yoshida, Y. Kawakami and K. Tsubota (2009). “Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.” Am J Pathol 175(6): 2372-2381.
- Morikawa, S., Y. Mabuchi, K. Niibe, S. Suzuki, N. Nagoshi, T. Sunabori, S. Shimmura, Y. Nagai, T. Nakagawa, H. Okano and Y. Matsuzaki (2009). “Development of mesenchymal stem cells partially originate from the neural crest.” Biochem Biophys Res Commun 379(4): 1114-1119.
- Morikawa, S., Y. Mabuchi, Y. Kubota, Y. Nagai, K. Niibe, E. Hiratsu, S. Suzuki, C. Miyauchi-Hara, N. Nagoshi, T. Sunabori, S. Shimmura, A. Miyawaki, T. Nakagawa, T. Suda, H. Okano and Y. Matsuzaki (2009). “Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow.” J Exp Med 206(11): 2483-2496.
- Ma, X., S. Shimmura, H. Miyashita, S. Yoshida, M. Kubota, T. Kawakita and K. Tsubota (2009). “Long-term culture and growth kinetics of murine corneal epithelial cells expanded from single corneas.” Invest Ophthalmol Vis Sci 50(6): 2716-2721.
- Kurihara, T., M. Omoto, K. Noda, M. Ebinuma, S. Kubota, H. Koizumi, S. Yoshida, Y. Ozawa, S. Shimmura, S. Ishida and K. Tsubota (2009). “Retinal phototoxicity in a novel murine model of intraocular lens implantation.” Mol Vis 15: 2751-2761.
- Kawashima, M., T. Kawakita, S. Yoshida, S. Shimmura and K. Tsubota (2009). “Nucleostemin as a possible progenitor marker of corneal epithelial cells.” Mol Vis 15: 1162-1168.
- Kawashima, M., T. Kawakita, S. Shimmura, K. Tsubota and J. Shimazaki (2009). “Characteristics of traumatic globe rupture after keratoplasty.” Ophthalmology 116(11): 2072-2076.
- Kawakita, T., S. Shimmura, K. Higa, E. M. Espana, H. He, J. Shimazaki, K. Tsubota and S. C. Tseng (2009). “Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets.” Invest Ophthalmol Vis Sci 50(10): 4611-4617.
- Higa, K., S. Shimmura, H. Miyashita, N. Kato, Y. Ogawa, T. Kawakita, J. Shimazaki and K. Tsubota (2009). “N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro.” Invest Ophthalmol Vis Sci 50(10): 4640-4645.
- Yuki, K., S. Shimmura, D. Shiba and K. Tsubota (2008). “Trabeculotomy for the treatment of glaucoma after Descemet stripping endothelial keratoplasty.” Br J Ophthalmol 92(9): 1299-1300.
- Uchino, M., D. A. Schaumberg, M. Dogru, Y. Uchino, K. Fukagawa, S. Shimmura, T. Satoh, T. Takebayashi and K. Tsubota (2008). “Prevalence of dry eye disease among Japanese visual display terminal users.” Ophthalmology 115(11): 1982-1988.
- Uchino, M., M. Dogru, Y. Uchino, K. Fukagawa, S. Shimmura, T. Takebayashi, D. A. Schaumberg and K. Tsubota (2008). “Japan Ministry of Health study on prevalence of dry eye disease among Japanese high school students.” Am J Ophthalmol 146(6): 925-929 e922.
- Tomita, M., S. Shimmura, K. Tsubota and J. Shimazaki (2008). “Postkeratoplasty atopic sclerokeratitis in keratoconus patients.” Ophthalmology 115(5): 851-856.
- Ozawa, Y., K. Nakao, T. Kurihara, T. Shimazaki, S. Shimmura, S. Ishida, A. Yoshimura, K. Tsubota and H. Okano (2008). “Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.” J Biol Chem 283(36): 24561-24570.
- Mochimaru, H., T. Usui, T. Yaguchi, Y. Nagahama, G. Hasegawa, Y. Usui, S. Shimmura, K. Tsubota, S. Amano, Y. Kawakami and S. Ishida (2008). “Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.” Invest Ophthalmol Vis Sci 49(5): 2172-2177.
- Miyashita, H., S. Shimmura, K. Higa, S. Yoshida, T. Kawakita, J. Shimazaki and K. Tsubota (2008). “A novel NIH/3T3 duplex feeder system to engineer corneal epithelial sheets with enhanced cytokeratin 15-positive progenitor populations.” Tissue Eng Part A 14(7): 1275-1282.
- Kawakita, T., S. Shimmura, A. Hornia, K. Higa and S. C. Tseng (2008). “Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell.” J Cell Mol Med 12(4): 1303-1316.
- Igarashi, T., S. Shimmura, S. Yoshida, M. Tonogi, N. Shinozaki and G. Y. Yamane (2008). “Isolation of oral epithelial progenitors using collagen IV.” Oral Dis 14(5): 413-418.
- Uchino, Y., S. Shimmura, H. Miyashita, T. Taguchi, H. Kobayashi, J. Shimazaki, J. Tanaka and K. Tsubota (2007). “Amniotic membrane immobilized poly(vinyl alcohol) hybrid polymer as an artificial cornea scaffold that supports a stratified and differentiated corneal epithelium.” J Biomed Mater Res B Appl Biomater 81(1): 201-206.
- Shimazaki, J., K. Higa, F. Morito, M. Dogru, T. Kawakita, Y. Satake, S. Shimmura and K. Tsubota (2007). “Factors influencing outcomes in cultivated limbal epithelial transplantation for chronic cicatricial ocular surface disorders.” Am J Ophthalmol 143(6): 945-953.
- Ozawa, Y., K. Nakao, T. Shimazaki, S. Shimmura, T. Kurihara, S. Ishida, A. Yoshimura, K. Tsubota and H. Okano (2007). “SOCS3 is required to temporally fine-tune photoreceptor cell differentiation.” Dev Biol 303(2): 591-600.
- Ogawa, Y., M. S. Razzaque, K. Kameyama, G. Hasegawa, S. Shimmura, M. Kawai, S. Okamoto, Y. Ikeda, K. Tsubota, Y. Kawakami and M. Kuwana (2007). “Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD.” Invest Ophthalmol Vis Sci 48(3): 1079-1086.
- Miyashita, H., K. Higa, N. Kato, T. Kawakita, S. Yoshida, K. Tsubota and S. Shimmura (2007). “Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro.” Invest Ophthalmol Vis Sci 48(8): 3586-3593.
- Matsumoto, Y., M. Dogru, E. A. Sato, Y. Katono, Y. Uchino, S. Shimmura and K. Tsubota (2007). “The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis.” Mol Vis 13: 1319-1326.
- Kato, N., S. Shimmura, T. Kawakita, H. Miyashita, Y. Ogawa, S. Yoshida, K. Higa, H. Okano and K. Tsubota (2007). “Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium.” Invest Ophthalmol Vis Sci 48(4): 1511-1517.
- Higuchi, A., R. Ueno, S. Shimmura, M. Suematsu, M. Dogru and K. Tsubota (2007). “Albumin rescues ocular epithelial cells from cell death in dry eye.” Curr Eye Res 32(2): 83-88.
- Higa, K., S. Shimmura, N. Kato, T. Kawakita, H. Miyashita, Y. Itabashi, K. Fukuda, J. Shimazaki and K. Tsubota (2007). “Proliferation and Differentiation of Transplantable Rabbit Epithelial Sheets Engineered with or without an Amniotic Membrane Carrier.” Invest Ophthalmol Vis Sci 48(2): 597-604.
- Dogru, M., N. Kato, Y. Matsumoto, Y. Tanaka, N. Akabane, S. Shimmura, K. Tsubota and J. Shimazaki (2007). “Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.” Curr Eye Res 32(10): 863-870.
- Den, S., S. Shimmura, K. Tsubota and J. Shimazaki (2007). “Impact of the descemet membrane perforation on surgical outcomes after deep lamellar keratoplasty.” Am J Ophthalmol 143(5): 750-754.
- Yoshida, S., S. Shimmura, N. Nagoshi, K. Fukuda, Y. Matsuzaki, H. Okano and K. Tsubota (2006). “Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea.” Stem Cells 24(12): 2714-2722.
- Yoshida, S., S. Shimmura, T. Kawakita, H. Miyashita, S. Den, J. Shimazaki and K. Tsubota (2006). “Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces.” Invest Ophthalmol Vis Sci 47(11): 4780-4786.
- Uchino, Y., E. Goto, Y. Takano, M. Dogru, N. Shinozaki, S. Shimmura, Y. Yagi, K. Tsubota and J. Shimazaki (2006). “Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency.” Ophthalmology 113(7): 1098-1101.
- Tomita, M., S. Shimmura, K. Tsubota and J. Shimazaki (2006). “Dacryoadenitis associated with Acanthamoeba keratitis.” Arch Ophthalmol 124(9): 1239-1242.
- Shimmura, S., H. Miyashita, Y. Uchino, T. Taguchi, H. Kobayashi, J. Shimazaki, J. Tanaka and K. Tsubota (2006). “Microkeratome assisted deep lamellar keratoprosthesis.” Br J Ophthalmol 90(7): 826-829.
- Shimmura, S., H. Miyashita, K. Higa, S. Yoshida, J. Shimazaki and K. Tsubota (2006). “Proteomic analysis of soluble factors secreted by limbal fibroblasts.” Mol Vis 12: 478-484.
- Shimazaki, J., K. Konomi, S. Shimmura and K. Tsubota (2006). “Ocular surface reconstruction for thermal burns caused by fireworks.” Cornea 25(2): 139-145.
- Miyashita, H., S. Shimmura, H. Kobayashi, T. Taguchi, N. Asano-Kato, Y. Uchino, M. Kato, J. Shimazaki, J. Tanaka and K. Tsubota (2006). “Collagen-immobilized poly(vinyl alcohol) as an artificial cornea scaffold that supports a stratified corneal epithelium.” J Biomed Mater Res B Appl Biomater 76(1): 56-63.
- Maruyama-Hosoi, F., J. Shimazaki, S. Shimmura and K. Tsubota (2006). “Changes Observed in Keratolimbal Allograft.” Cornea 25(4): 377-382.
- Kawashima, M., T. Kawakita, S. Den, S. Shimmura, K. Tsubota and J. Shimazaki (2006). “Comparison of deep lamellar keratoplasty and penetrating keratoplasty for lattice and macular corneal dystrophies.” Am J Ophthalmol 142(2): 304-309.
- Higuchi, A., S. Shimmura, T. Takeuchi, M. Suematsu and K. Tsubota (2006). “Elucidation of apoptosis induced by serum deprivation in cultured conjunctival epithelial cells.” Br J Ophthalmol 90(6): 760-764.
- Higa, K., S. Shimmura, J. Shimazaki and K. Tsubota (2006). “Ocular surface epithelial cells up-regulate HLA-G when expanded in vitro on amniotic membrane substrates.” Cornea 25(6): 715-721.
- Den, S., K. Shimizu, T. Ikeda, K. Tsubota, S. Shimmura and J. Shimazaki (2006). “Association between meibomian gland changes and aging, sex, or tear function.” Cornea 25(6): 651-655.
- Den, S., M. Dogru, N. Kato, Y. Tanaka, S. Shimmura and J. Shimazaki (2006). “Disseminated keratoconjunctival epitheliopathy in a patient with systemic lupus erythematosus.” Br J Ophthalmol 90(8): 1068-1070.
- Yoshida, S., S. Shimmura, J. Shimazaki, N. Shinozaki and K. Tsubota (2005). “Serum-free spheroid culture of mouse corneal keratocytes.” Invest Ophthalmol Vis Sci 46(5): 1653-1658.
- Shimmura, S., J. Shimazaki, M. Omoto, A. Teruya, M. Ishioka and K. Tsubota (2005). “Deep lamellar keratoplasty (DLKP) in keratoconus patients using viscoadaptive viscoelastics.” Cornea 24(2): 178-181.
- Shimmura, S., M. Omoto, S. Den, H. Bissen-Miyajima, K. Tsubota and J. Shimazaki (2005). “Microkeratome-assisted phacoemulsification.” J Cataract Refract Surg 31(9): 1699-1701.
- Shimmura, S., H. Miyashita, K. Konomi, N. Shinozaki, T. Taguchi, H. Kobayashi, J. Shimazaki, J. Tanaka and K. Tsubota (2005). “Transplantation of corneal endothelium with Descemet’s membrane using a hyroxyethyl methacrylate polymer as a carrier.” Br J Ophthalmol 89(2): 134-137.
- Higa, K., S. Shimmura, J. Shimazaki and K. Tsubota (2005). “Hyaluronic acid-CD44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma.” Cornea 24(2): 206-212.
- Higa, K., S. Shimmura, H. Miyashita, J. Shimazaki and K. Tsubota (2005). “Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells.” Exp Eye Res 81(2): 218-223.
- Dogru, M., N. Asano-Kato, M. Tanaka, A. Igarashi, S. Shimmura, J. Shimazaki, N. Okada, Y. Takano, K. Fukagawa, K. Tsubota and H. Fujishima (2005). “Ocular Surface and MUC5AC Alterations in Atopic Patients with Corneal Shield Ulcers.” Curr Eye Res 30(10): 897-908.
- Shimmura, S., K. Tadano and K. Tsubota (2004). “UV dose-dependent caspase activation in a corneal epithelial cell line.” Curr Eye Res 28(2): 85-92.
- Shimmura, S., M. Ando, M. Ishioka, J. Shimazaki and K. Tsubota (2004). “Same-size donor corneas for myopic keratoconus.” Cornea 23(4): 345-349.
- Shimazaki, J., N. Shinozaki, S. Shimmura, E. J. Holland and K. Tsubota (2004). “Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation.” Transplantation 78(2): 216-220.
- Shimazaki, J., S. Shimmura and K. Tsubota (2004). “Donor source affects the outcome of ocular surface reconstruction in chemical or thermal burns of the cornea.” Ophthalmology 111(1): 38-44.
- Konomi, K., J. Shimazaki, S. Shimmura, N. Akabane, E. Goto and K. Tsubota (2004). “Efficacy of core vitrectomy preceding triple corneal procedure.” Br J Ophthalmol 88(8): 1023-1025.
- Kobayashi, H., M. Kato, T. Taguchi, T. Ikoma, H. Miyashita, S. Shimmura, K. Tsubota and J. Tanaka (2004). “Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea ” Mater Sci Eng C 24: 729-735.
- Dogru, M., B. Kaderli, O. Gelisken, A. Yucel, R. Avci, E. Goto, S. Shimmura, J. Shimazaki and K. Tsubota (2004). “Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus.” Am J Ophthalmol 138(3): 381-388.
- Bissen-Miyajima, H., K. Nakamura, M. Kaido, S. Shimmura and K. Tsubota (2004). “Role of the endothelial pump in flap adhesion after laser in situ keratomileusis.” J Cataract Refract Surg 30(9): 1989-1992.
- Shimmura, S., R. Ueno, Y. Matsumoto, E. Goto, A. Higuchi, J. Shimazaki and K. Tsubota (2003). “Albumin as a tear supplement in the treatment of severe dry eye.” Br J Ophthalmol 87(10): 1279-1283.
- Shimmura, S., J. Shimazaki and K. Tsubota (2003). “Therapeutic deep lamellar keratoplasty for cornea perforation.” Am J Ophthalmol 135(6): 896-897.
- Shimmura, S., Y. Ohashi, H. Shiroma, J. Shimazaki and K. Tsubota (2003). “Corneal opacity and cataract: triple procedure versus secondary approach.” Cornea 22(3): 234-238.
- Shimmura, S., R. Igarashi, H. Yaguchi, Y. Ohashi, J. Shimazaki and K. Tsubota (2003). “Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers.” Am J Ophthalmol 135(5): 613-619.
- Shimmura, S., C. J. Doillon, M. Griffith, M. Nakamura, E. Gagnon, A. Usui, N. Shinozaki and K. Tsubota (2003). “Collagen-poly(N-isopropylacrylamide)-based membranes for corneal stroma scaffolds.” Cornea 22(7 Suppl): S81-88.
- Shimazaki, J., K. Kosaka, S. Shimmura and K. Tsubota (2003). “Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium.” Ophthalmology 110(1): 119-124.
- Mori, A., J. Shimazaki, S. Shimmura, H. Fujishima, Y. Oguchi and K. Tsubota (2003). “Disposable eyelid-warming device for the treatment of meibomian gland dysfunction.” Jpn J Ophthalmol 47(6): 578-586.
- Asano-Kato, N., I. Toda, S. Shimmura, T. Noda-Tsuruya, K. Fukagawa, M. Yoshinaga, A. Matsukawa and K. Tsubota (2003). “Detection of neutrophils and possible involvement of interleukin-8 in diffuse lamellar keratitis after laser in situ keratomileusis.” J Cataract Refract Surg 29(10): 1996-2000.
- Tsubota, K., S. Shimmura, N. Shinozaki, E. J. Holland and J. Shimazaki (2002). “Clinical application of living-related conjunctival-limbal allograft.” Am J Ophthalmol 133: 134-135.
- Takahashi, H., A. Sakamoto, R. Takahashi, T. Ohmura, S. Shimmura and K. Ohara (2002). “Free radicals in phacoemulsification and aspiration procedures.” Arch Ophthalmol 120(10): 1348-1352.
- Shimazaki, J., S. Shimmura and K. Tsubota (2002). “Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).” Cornea 21(2): 177-180.
- Shimazaki, J., S. Shimmura, M. Ishioka and K. Tsubota (2002). “Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty(1).” Am J Ophthalmol 134(2): 159-165.
- Shimazaki, J., M. Aiba, E. Goto, N. Kato, S. Shimmura and K. Tsubota (2002). “Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders.” Ophthalmology 109(7): 1285-1290.
- Higuchi, A., S. Shimmura, M. Ishii, H. Aburatani and K. Tsubota (2002). “Serum- and serum deprivation-induced transcriptional profiles of cultured conjunctival epithelial cells.” Adv Exp Med Biol 506(Pt A): 673-676.
- Goto, E., J. Shimazaki, Y. Monden, Y. Takano, Y. Yagi, S. Shimmura and K. Tsubota (2002). “Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction.” Ophthalmology 109(11): 2030-2035.
- Goto, E., Y. Monden, Y. Takano, A. Mori, S. Shimmura, J. Shimazaki and K. Tsubota (2002). “Treatment of non-inflamed obstructive meibomian gland dysfunction by an infrared warm compression device.” Br J Ophthalmol 86(12): 1403-1407.
- Shimmura, S., J. Shimazaki, Y. Ohashi and K. Tsubota (2001). “Anti-inflammatory effects of amniotic membrane transplantation in ocular surface disorders.” Cornea 20: 408-413.
- Shimazaki, J., F. Maruyama, S. Shimmura, H. Fujishima and K. Tsubota (2001). “Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty.” Cornea 20(2): 149-152.
- Miyoshi, T., K. Fukagawa, S. Shimmura, H. Fujishima, Y. Takano, E. Takamura, K. Tsubota, H. Saito and Y. Oguchi (2001). “Interleukin-8 concentrations in conjunctival epithelium brush cytology samples correlate with neutrophil, eosinophil infiltration, and corneal damage.” Cornea 20(7): 743-747.
- Ishioka, M., S. Shimmura, Y. Yagi and K. Tsubota (2001). “Pterygium and dry eye.” Ophthalmologica 215(3): 209-211.
- Hanada, K., J. Shimazaki, S. Shimmura and K. Tsubota (2001). “Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera.” Am J Ophthalmol 131(3): 324-331.
- Goto, E., S. Shimmura, J. Shimazaki and K. Tsubota (2001). “Treatment of superior limbic keratoconjunctivitis by application of autologous serum.” Cornea 20(8): 807-810.
- Shimmura, S., K. Matsumoto, H. Yaguchi, T. Okuda, S. Miyajima, A. Negi, J. Shimazaki and K. Tsubota (2000). “Acidic electrolyzed water in the disinfection of the ocular surface.” Exp Eye Res 70: 1-6.
- Shimmura, S., M. Ishioka, K. Hanada, J. Shimazaki and K. Tsubota (2000). “Telomerase activity and p53 expression in pterygia.” Invest Ophthalmol Vis Sci 41(6): 1364-1369.
- Shimmura, S., M. Ando, J. Shimazaki and K. Tsubota (2000). “Complications with one-piece lamellar kerato-limbal grafts for simultaneous limbal and corneal pathologies.” Cornea 19(4): 439-442.
- Shimazaki, S., S. Shimmura, H. Fujishima and K. Tsubota (2000). “Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome.” Ophthalmology 107: 1518-1523.
- Shimazaki, J., K. Hanada, Y. Yagi, J. Yamagami, M. Ishioka, S. Shimmura and K. Tsubota (2000). “Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol v 0. 12% unoprostone.” Br J Ophthalmol 84(11): 1250-1254.
- Nakamura, K., H. Bissen-Miyajima, S. Shimmura and K. Tsubota (2000). “Clinical application of Er:YAG laser for the treatment of pterygium.” Ophthalmic Surg Lasers 31(1): 8-12.
- Ishioka, M., J. Shimazaki, J. Yamagami, H. Fujishima, S. Shimmura and K. Tsubota (2000). “Trabeculectomy with mitomycin C for post-keratoplasty glaucoma.” Br J Ophthalmol 84: 714-717.
- Fukagawa, K., T. Nakajima, H. Saito, K. Tsubota, S. Shimmura, M. Natori and K. Hirai (2000). “IL-4 induces eotaxin production in corneal keratocytes but not in epithelial cells.” Int Arch Allergy Immunol 121: 144-150.
- Tsubota, K., Y. Satake, M. Kaido, N. Shinozaki, S. Shimmura, H. Bissen-Miyajima and J. Shimazaki (1999). “Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation.” N Engl J Med 340(22): 1697-1703.
- Tsubota, K., Y. Monden, Y. Yagi, E. Goto and S. Shimmura (1999). “New treatement of dry eye. The effect of calcium ointment through eyelid skin delivery.” Br J Ophthalmol 83: 767-770.
- Tsubota, K., M. Kaido, Y. Yagi, T. Fujihara and S. Shimmura (1999). “Diseases associated with ocular surface abnormalities: The importance of reflex tearing.” Br J Ophthalmol 83: 89-91.
- Tsubota, K., E. Goto, S. Shimmura and J. Shimazaki (1999). “Treatment of persistent corneal epithelial defect by autologous serum application.” Ophthalmology 106: 1984-1989.
- Tsubota, K., E. Goto, H. Fujita, M. Ono, H. Inoue, I. Saito and S. Shimmura (1999). “Treatment of dry eye by autologus serum application in Sjogren’s Syndrome.” Br J Ophthalmol 83: 390-395.
- Tsubota, K., K. Fukagawa, T. Fujihara, S. Shimmura, I. Saito, K. Saito and T. Takeuchi (1999). “Regulation of HLA DR expression in human conjunctival epithelium.” Invest Ophthalmol Vis Sci 40: 28-34.
- Takano, Y., K. Fukagawa, S. Shimmura, K. Tsubota, Y. Oguchi and H. Saito (1999). “IL-4 regulates chemokine production induced by TNF-a in keratocytes and corneal epithelial cells.” Br J Ophthalmol 83: 1074-1076.
- Shimmura, S., J. Shimazaki and K. Tsubota (1999). “Results of a population -based questionnaire on the symptoms and lifestyles associated with dry eye.” Cornea 18: 408-411.
- Shimmura, S., T. Masumizu, K. Urayama, J. Shimazaki, H. Bissen-Miyajima and K. Tsubota (1999). “Excimer laser-induced hydroxyl radical formation and keratocyte death in vitro.” Invest Ophthalmol Vis Sci 40: 1245-1249.
- Shimazaki, J., S. Shimmura, K. Yamato and K. Tsubota (1999). “Morphology and barrier function of the corneal epithelium following penetrating keratoplasty: association with original diseases, tear function, and suture removal.” Cornea 18: 559-564.
- Shimazaki, J., M. Kaido, N. Shinozaki, S. Shimmura, B. Munkhbat, M. Hagihara, K. Tsuji and K. Tsubota (1999). “Evidence of long-term survival of donor-derived cells after limbal allograft transplantation.” Invest Ophthalmol Vis Sci 40: 1664-1668.
- Nakamura, K., H. Bissen-Miyajima, H. Arai, I. Toda, Y. Hori, S. Shimmura and K. Tsubota (1999). “Iatrogenic cataract after laser-assisted in situ keratomileusis.” Am J Ophthalmol 128: 507-509.
- Fukagawa, K., T. Nakajima, K. Tsubota, S. Shimmura, H. Saito and K. Hirai (1999). “Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage.” J Allergy Clin Immunol 103: 1220-1221.
- Bissen-Miyajima, H., S. Shimmura and K. Tsubota (1999). “Thermal effect on corneal incisions with different ultrasonic tips.” J Cataract Refract Surg 25: 60-64.
- Shimmura, S., N. Shinozaki, K. Fukagawa, J. Shimazaki and K. Tsubota (1998). “Real-time telemedicine in the clinical assessment of the ocular surface.” Am J Ophthalmol 125: 388-390.
- Shimmura, S., M. Shimoyama, M. Hojo, K. Urayama and K. Tsubota (1998). “Reoxygenation injury in a cultured corneal epithelial cell line protected by the uptake of lactoferrin.” Invest Ophthalmol Vis Sci 39: 1346-1351.
- Shimmura, S., K. Matsumoto, E. Goto, K. Saito, T. Takeuchi, S. Miyajima, A. Negi and K. Tsubota (1998). “Lecithin-bound superoxide dismutase in the prevention of neutrophil-induced damage of corneal tissue.” Invest Ophthalmol Vis Sci 39: 30-35.
- Shimmura, S., E. Goto, J. Shimazaki and K. Tsubota (1998). “Viscosity-dependent fluid dynamics of eyedrops on the ocular surface.” Am J Ophthalmol 125(3): 386-388.
- Shimazaki, J., H.-Y. Yang, S. Shimmura and K. Tsubota (1998). “Terrien’s marginal degeneration associated with erythema elevatum diutinum.” Cornea 17: 342-344.
- Shimazaki, J., S. Shimmura and K. Tsubota (1998). “Intraoperative versus postoperative suture adjustment after penetrating keratoplasty.” Cornea 17: 590-594.
- Shimazaki, J., E. Goto, M. Ono, S. Shimmura and K. Tsubota (1998). “Meibomian gland dysfunction in patients with Sjogren syndrome.” Ophthalmology 105: 1485-1488.
- Shimoyama, M., S. Shimmura, K. Tsubota and Y. Oguchi (1997). “Suppression of nuclear factor kappa B and CD 18 mediated leukocyte adhesion to the corneal endothelium by dexamethasone.” Invest Ophthalmol Vis Sci 38(11): 2427-2431.
- Shimmura, S., H.-Y. Yang, H. Bissen-Miyajima, J. Shimazaki and K. Tsubota (1997). “Posterior corneal protrusion following PRK.” Cornea 16: 686-688.
- Shimmura, S. and K. Tsubota (1997). “Ultraviolet B-induced mitochondrial dysfunction is associated with decreased cell detachment of corneal epithelial cells in vitro.” Invest Ophthalmol Vis Sci 38(3): 620-626.
- Shimmura, S., N. Shinozaki, K. Fukagawa and K. Tsubota (1997). “Telemedicine in the follow-up of corneal transplant patients.” J Telemed Telecare 3(4): 227-228.
- Fukagawa, K., H. Saito, K. Tsubota, S. Shimmura, H. Tachimoto, A. Akasawa and Y. Oguchi (1997). “RANTES production in a conjunctival epithelial cell line.” Cornea 16: 564-570.
- Shimmura, S., M. Suematsu, M. Shimoyama, K. Tsubota, Y. Oguchi and Y. Ishimura (1996). “Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells: the protective effects of lactoferrin.” Exp Eye Res 63(5): 519-526.
- Shimmura, S., M. Ono, K. Shinozaki, I. Toda, E. Takamura, Y. Mashima and K. Tsubota (1995). “Sodium hyaluronate eyedrops in the treatment of dry eyes.” Br J Ophthalmol 79(11): 1007-1011.
- Shimmura, S., K. Tsubota, Y. Oguchi, D. Fukumura, M. Suematsu and M. Tsuchiya (1992). “Oxiradical-dependent photoemission induced by a phacoemulsification probe.” Invest Ophthalmol Vis Sci 33(10): 2904-2907.
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