研究業績

1. Hirayama M, Hatou S, Nomura M, Hokama R, Hirayama OI, Inagaki E, Aso K, Sayano T, Dohi H, Hanatani T, Takasu N, Okano H, Negishi K, Shimmura S. One year course of a first-in-human clinical study of an allogenic iPSC-derived corneal endothelial cell substitute transplantation for bullous keratopathy. Cell Reports Medicine. ( 2024. In press.)
2. RuschR, Inagaki E ,Taniguchi H, Sakakura, Tamai R,Nonaka H , Shimizu S , Sato S,Ogawa Y, Hirayama M, Negishi K, Okano H , Shimmura S .Adipose-Derived Mesenchymal Stromal Cells: A Study on Safety and Efficacy in Ocular Inflammation.The Ocular Surfac.(Available online 13 November 2024)
3. Sakakura S, Yamazaki R, Uchino Y, Negishi K, Shimmura S.”Non-Descemet stripping endothelial keratoplasty for bullous keratopathy in patients with atopic dermatitis: A long-term case report.”（2024)　Medicine (Baltimore) 27;103(39)
4. Asai K, Lee HK, Sato S, Shimizu E, Jung J, Okazaki T, Ogawa M, Shimmura S, Tsubota K, Ogawa Y, Negishi K, Hirayama M.”The Necroptosis Pathway Is Upregulated in the Cornea in Mice With Ocular Graft-Versus-Host Disease.”（2024) Invest Ophthalmol Vis Sci. 65(10):38.
5. Sato S, Ogawa Y, Shimizu E, Asai K, Okazaki T, Rusch R, Hirayama M, Shimmura S, Negishi K, Tsubota K.” Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model.”（2024) Ocul Surf32:198-210
6. Shimmura S, Inagaki E, Hirayama M, Hatou S.The Cornea（2024）”The Cornea: An Ideal Tissue for Regenerative Medicine.”Keio J Med73(1):1-7.
7. ISCT2024 Vancouver Canada.Shimmura S.The State of iPSC-Derived Cell Therapies and Accelerating Clinical POC”Allogeneic iPSC-derived corneal endothelial substitutes for bullous keratopathy”May 30, 2024.
8. 33rd Biennial Cornea Conference. Lisbon, Portugal.Shimmura S,Immunomodulation of Corneal Disease With Adipose-Derived Mesenchymal Stromal/Stem Cells .October 4, 2024.
9. Sakakura, S., E. Inagaki, Y. Ochiai, M. Yamamoto, N. Takai, T. Nagata, K. Higa, Y. Sato, H. Toshida, D. Murat, M. Hirayama, Y. Ogawa, K. Negishi and S. Shimmura (2023). “A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model.” Int J Mol Sci 24(22).
10. Altshuler, A., A. Amitai-Lange, W. Nasser, S. Dimri, S. Bhattacharya, B. Tiosano, R. Barbara, D. Aberdam, S. Shimmura and R. Shalom-Feuerstein (2023). “Eyes open on stem cells.” Stem Cell Reports.
11. Sakakura, S., E. Inagaki, T. Sayano, R. Yamazaki, N. Fusaki, S. Hatou, M. Hirayama, K. Tsubota, K. Negishi, H. Okano and S. Shimmura (2023). “Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy.” Regen Ther 24: 592-60
12. Terai, H., M. Ishii, R. Takemura, H. Namkoong, K. Shimamoto, K. Masaki, T. Tanosaki, S. Chubachi, E. Matsuyama, R. Hayashi, T. Shimada, L. Shigematsu, F. Ito, M. Kaji, H. Takaoka, M. Kurihara, K. Nakagawara, S. Tomiyasu, K. Sasahara, A. Saito, S. Otake, S. Azekawa, M. Okada, T. Fukushima, A. Morita, H. Tanaka, K. Sunata, M. Asaoka, M. Nishie, T. Shinozaki, T. Ebisudani, Y. Akiyama, A. Mitsuishi, S. Nakayama, T. Ogawa, K. Sakurai, M. Irie, K. Yagi, K. Ohgino, J. Miyata, H. Kabata, S. Ikemura, H. Kamata, H. Yasuda, I. Kawada, R. Kimura, M. Kondo, T. Iwasaki, N. Ishida, G. Hiruma, N. Miyazaki, Y. Ishibashi, S. Harada, T. Fujita, D. Ito, S. Bun, H. Tabuchi, S. Kanzaki, E. Shimizu, K. Fukuda, J. Yamagami, K. Kobayashi, T. Hirano, T. Inoue, M. Haraguchi, J. Kagyo, T. Shiomi, H. Lee, K. Sugihara, N. Omori, K. Sayama, K. Otsuka, N. Miyao, T. Odani, M. Watase, T. Mochimaru, R. Satomi, Y. Oyamada, K. Masuzawa, T. Asakura, S. Nakayama, Y. Suzuki, R. Baba, S. Okamori, D. Arai, I. Nakachi, N. Kuwahara, A. Fujiwara, T. Oakada, T. Ishiguro, T. Isosno, Y. Makino, S. Mashimo, T. Kaido, N. Minematsu, S. Ueda, K. Minami, R. Hagiwara, T. Manabe, T. Fukui, Y. Funatsu, H. Koh, T. Yoshiyama, H. Kokuto, T. Kusumoto, A. Oashi, M. Miyawaki, F. Saito, T. Tani, K. Ishioka, S. Takahashi, M. Nakamura, N. Harada, H. Sasano, A. Goto, Y. Kusaka, T. Ohba, Y. Nakano, K. Nishio, Y. Nakajima, S. Suzuki, S. Yoshida, H. Tateno, N. Kodama, M. Shunsuke, S. Sakamoto, M. Okamoto, Y. Nagasaki, A. Umeda, K. Miyagawa, H. Shimada, K. Hagimura, K. Nagashima, T. Sato, Y. Sato, N. Hasegawa, T. Takebayashi, J. Nakahara, M. Mimura, K. Ogawa, S. Shimmura, K. Negishi, K. Tsubota, M. Amagai, R. Goto, Y. Ibuka, Y. Kitagawa, T. Kanai and K. Fukunaga (2023). “Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study.” Respir Investig 61(6): 802-814.
13. Shimizu, E., S. Sato, K. Asai, Y. Ogawa, S. Shimmura and K. Negishi (2023). “Clinical Features of Sjogren Syndrome-Related Dry Eye Disease in Anterior Segment Photographs.” Cornea.
14. Hatou, S. and S. Shimmura (2023). “Advances in corneal regenerative medicine with iPS cells.” Jpn J Ophthalmol 67(5): 541-545.
15. Matsumae, H., T. Yamaguchi, Y. Kusano, S. Shimmura, A. Kobayashi, Y. Morizane and J. Shimazaki (2022). “Graft Size and Double Scroll Formation Rate in Descemet Membrane Endothelial Keratoplasty.” Curr Eye Res 47(9): 1246-1251.
16. Inagaki, E., E. Arai, S. Hatou, T. Sayano, H. Taniguchi, K. Negishi, Y. Kanai, Y. Sato, H. Okano, K. Tsubota and S. Shimmura (2022). “The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.” Stem Cells Transl Med 11(8): 841-849.
17. Shimizu, S., S. Sato, H. Taniguchi, E. Shimizu, J. He, S. Hayashi, K. Negishi, Y. Ogawa and S. Shimmura (2021). “Observation of Chronic Graft-Versus-Host Disease Mouse Model Cornea with In Vivo Confocal Microscopy.” Diagnostics (Basel) 11(8).
18. Rusch, R. M., Y. Ogawa, S. Sato, S. Morikawa, E. Inagaki, E. Shimizu, K. Tsubota and S. Shimmura (2021). “MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation.” Int J Mol Sci 22(9).
19. Nakagawara, K., H. Namkoong, H. Terai, K. Masaki, T. Tanosaki, K. Shimamoto, H. Lee, H. Tanaka, S. Okamori, H. Kabata, S. Chubachi, S. Ikemura, H. Kamata, H. Yasuda, I. Kawada, M. Ishii, Y. Ishibashi, S. Harada, T. Fujita, D. Ito, S. Bun, H. Tabuchi, S. Kanzaki, E. Shimizu, K. Fukuda, J. Yamagami, K. Kobayashi, T. Hirano, T. Inoue, J. Kagyo, T. Shiomi, K. Ohgino, K. Sayama, K. Otsuka, N. Miyao, T. Odani, Y. Oyamada, K. Masuzawa, S. Nakayama, Y. Suzuki, R. Baba, I. Nakachi, N. Kuwahara, T. Ishiguro, S. Mashimo, N. Minematsu, S. Ueda, T. Manabe, Y. Funatsu, H. Koh, T. Yoshiyama, F. Saito, K. Ishioka, S. Takahashi, M. Nakamura, A. Goto, N. Harada, Y. Kusaka, Y. Nakano, K. Nishio, H. Tateno, R. Edahiro, Y. Takeda, A. Kumanogoh, N. Kodama, M. Okamoto, A. Umeda, K. Hagimura, T. Sato, N. Miyazaki, R. Takemura, Y. Sato, T. Takebayashi, J. Nakahara, M. Mimura, K. Ogawa, S. Shimmura, K. Negishi, K. Tsubota, M. Amagai, R. Goto, Y. Ibuka, N. Hasegawa, Y. Kitagawa, T. Kanai and K. Fukunaga (2021). “Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol.” BMJ Open Respir Res 8(1).
20. Hatou, S., T. Sayano, K. Higa, E. Inagaki, Y. Okano, Y. Sato, H. Okano, K. Tsubota and S. Shimmura (2021). “Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model.” Stem Cell Res 55: 102497.
21. Hata-Mizuno, M., Y. Uchino, M. Uchino, S. Shimmura, Y. Ogawa, K. Tsubota and K. Negishi (2021). “Analysis of the Association between Galectin-3 Concentration in Tears and the Severity of Dry Eye Disease: A Case-Control Study.” J Clin Med 11(1).
22. Yamazaki, R., R. Nejima, Y. Ichihashi, K. Miyata, K. Tsubota and S. Shimmura (2020). “Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy.” Jpn J Ophthalmol 64(6): 585-590.
23. Yamane, M., S. Sato, E. Shimizu, S. Shibata, M. Hayano, T. Yaguchi, H. Kamijuku, M. Ogawa, T. Suzuki, S. Mukai, S. Shimmura, H. Okano, T. Takeuchi, Y. Kawakami, Y. Ogawa and K. Tsubota (2020). “Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.” FASEB J 34(8): 10778-10800.
24. Higa, K., J. Higuchi, R. Kimoto, H. Miyashita, J. Shimazaki, K. Tsubota and S. Shimmura (2020). “Human corneal limbal organoids maintaining limbal stem cell niche function.” Stem Cell Res 49: 102012.
25. Hata-Mizuno, M., E. Ingaki, H. Mitamura, Y. Uchino, K. Tsubota and S. Shimmura (2020). “Conjunctival Epithelial Ingrowth After Penetrating Keratoplasty.” Cornea 39(9): 1181-1183.
26. Yamashita, K., S. Hatou, Y. Uchino, K. Tsubota and S. Shimmura (2019). “Prognosis after lamellar keratoplasty for limbal dermoids using preserved corneas.” Jpn J Ophthalmol 63(1): 56-64.
27. Venkatraman, A., G. Hochart, D. Bonnel, J. Stauber, S. Shimmura, L. Rajamani, K. Pervushin and J. S. Mehta (2019). “Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI-H626R and TGFBI-R124C Mutations.” Proteomics Clin Appl 13(1): e1800053.
28. Fujii, S., S. Yoshida, E. Inagaki, S. Hatou, K. Tsubota, M. Takahashi, S. Shimmura and S. Sugita (2019). “Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells.” Stem Cells Dev 28(1): 28-43.
29. Deng, S. X., V. Borderie, C. C. Chan, R. Dana, F. C. Figueiredo, J. A. P. Gomes, G. Pellegrini, S. Shimmura, F. E. Kruse and G. and The International Limbal Stem Cell Deficiency Working (2019). “Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency.” Cornea 38(3): 364-375.
30. Yamashita, K., E. Inagaki, S. Hatou, K. Higa, A. Ogawa, H. Miyashita, K. Tsubota and S. Shimmura (2018). “Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord.” Stem Cells Dev 27(16): 1097-1108.
31. Yamashita, K., S. Hatou, E. Inagaki, K. Higa, K. Tsubota and S. Shimmura (2018). “A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells.” Sci Rep 8(1): 16868.
32. Yamane, M., Y. Ogawa, S. Mukai, S. Yaguchi, H. Kamijuku, T. Inaba, K. Asai, S. Morikawa, Y. Kawakami, S. Shimmura and K. Tsubota (2018). “Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease.” Cornea 37(1): 102-108.
33. Den, S., S. Shimmura and J. Shimazaki (2018). “Cataract surgery after deep anterior lamellar keratoplasty and penetrating keratoplasty in age- and disease-matched eyes.” J Cataract Refract Surg 44(4): 496-503.
34. Yamazaki, R., K. Yamazoe, S. Yoshida, S. Hatou, E. Inagaki, H. Okano, K. Tsubota and S. Shimmura (2017). “The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model.” Sci Rep 7(1): 15584.
35. Shimmura-Tomita, M., S. Shimmura, K. Tsubota and J. Shimazaki (2017). “Penetrating Keratoplasty Performed by Residents Compared With an Experienced Cornea Transplant Surgeon.” J Surg Educ 74(2): 258-263.
36. Miyashita, H., H. Niwano, S. Yoshida, S. Hatou, E. Inagaki, K. Tsubota and S. Shimmura (2017). “Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model.” Sci Rep 7: 43557.
37. Inagaki, E., S. Hatou, K. Higa, S. Yoshida, S. Shibata, H. Okano, K. Tsubota and S. Shimmura (2017). “Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration.” Stem Cells Transl Med 6(3): 788-798.
38. Hirayama, M., S. B. H. Ko, T. Kawakita, T. Akiyama, S. K. Goparaju, A. Soma, Y. Nakatake, M. Sakota, N. Chikazawa-Nohtomi, S. Shimmura, K. Tsubota and M. S. H. Ko (2017). “Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells.” NPJ Aging Mech Dis 3: 1.
39. Ogawa, Y., S. Morikawa, H. Okano, Y. Mabuchi, S. Suzuki, T. Yaguchi, Y. Sato, S. Mukai, S. Yaguchi, T. Inaba, S. Okamoto, Y. Kawakami, K. Tsubota, Y. Matsuzaki and S. Shimmura (2016). “MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.” Elife 5: e09394.
40. Ogawa, A., Y. Matsumoto, T. Yaguchi, S. Shimmura and K. Tsubota (2016). “Successful treatment of Beauveria bassiana fungal keratitis with topical voriconazole.” J Infect Chemother 22(4): 257-260.
41. Ishiyama, S., Y. Mori, R. Nejima, T. Tokudome, S. Shimmura, K. Miyata and S. Amano (2016). “Comparison of Long-Term Outcomes of Visual Function and Endothelial Cell Survival After Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty Using Mixed-Effects Models.” Cornea.
42. Hirayama, M., Y. Liu, T. Kawakita, S. Shimmura and K. Tsubota (2016). “Cytokeratin expression in mouse lacrimal gland germ epithelium.” Exp Eye Res 146: 54-59.
43. Yamazoe, K., S. Yoshida, M. Yasuda, S. Hatou, E. Inagaki, Y. Ogawa, K. Tsubota and S. Shimmura (2015). “Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2.” PLoS One 10(7): e0133397.
44. Yaguchi, S., Y. Ogawa, T. Kawakita, S. Shimmura and K. Tsubota (2015). “Tissue Renin-Angiotensin System in Lacrimal Gland Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease.” Cornea 34 Suppl 11: S142-152.
45. Kawakita, T., S. Shimmura and K. Tsubota (2015). “Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjogren Syndrome.” Asia Pac J Ophthalmol (Phila) 4(2): 101-105.
46. Kamoshita, M., Y. Matsumoto, K. Nishimura, Y. Katono, M. Murata, Y. Ozawa, S. Shimmura and K. Tsubota (2015). “Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin.” J Infect Chemother 21(2): 141-143.
47. Fukui, M., Y. Ogawa, S. Shimmura, S. Hatou, Y. Ichihashi, S. Yaguchi, M. Hirayama, T. Kawakita and K. Tsubota (2015). “Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz’s disease.” Mod Rheumatol: 1-7.
48. Yoshida, T., Y. Ozawa, K. Suzuki, K. Yuki, M. Ohyama, W. Akamatsu, Y. Matsuzaki, S. Shimmura, K. Mitani, K. Tsubota and H. Okano (2014). “The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.” Mol Brain 7: 45.
49. Shiba, D., S. Hatou, T. Ono, S. Hosoda, S. Tanabe, N. Ozeki, K. Yuki, M. Shimoyama, K. Fukagawa, S. Shimmura and K. Tsubota (2014). “Multivariable logistic regression model: a novel mathematical model that predicts visual field sensitivity from macular ganglion cell complex thickness in glaucoma.” PLoS One 9(8): e104126.
50. Satake, Y., T. Yamaguchi, M. Hirayama, K. Higa, S. Shimazaki-Den, M. Dogru, T. Kawakita, M. Kawashima, S. Shimmura, K. Tsubota and J. Shimazaki (2014). “Ocular surface reconstruction by cultivated epithelial sheet transplantation.” Cornea 33 Suppl 11: S42-46.
51. Kamoshita, M., Y. Ozawa, S. Kubota, S. Miyake, C. Tsuda, N. Nagai, K. Yuki, S. Shimmura, K. Umezawa and K. Tsubota (2014). “AMPK-NF-kappaB axis in the photoreceptor disorder during retinal inflammation.” PLoS One 9(7): e103013.
52. Fujii, S., Y. Matsumoto, M. Fukui, J. Fujitake, T. Kawakita, S. Shimmura and K. Tsubota (2014). “Clinical backgrounds of postoperative keratoplasty patients with spontaneous wound dehiscence or gaps after suture removal.” Cornea 33(12): 1320-1323.
53. Yaguchi, S., Y. Ogawa, S. Shimmura, T. Kawakita, S. Hatou, S. Satofuka, S. Nakamura, T. Imada, H. Miyashita, S. Yoshida, T. Yaguchi, Y. Ozawa, T. Mori, S. Okamoto, Y. Kawakami, S. Ishida and K. Tsubota (2013). “Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease.” PLoS One 8(6): e64724.
54. Narimatsu, T., Y. Ozawa, S. Miyake, S. Kubota, M. Hirasawa, N. Nagai, S. Shimmura and K. Tsubota (2013). “Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice.” Invest Ophthalmol Vis Sci 54(7): 4555-4562.
55. Miyashita, H., S. Yokoo, S. Yoshida, T. Kawakita, S. Yamagami, K. Tsubota and S. Shimmura (2013). “Long-term maintenance of limbal epithelial progenitor cells using rho kinase inhibitor and keratinocyte growth factor.” Stem Cells Transl Med 2(10): 758-765.
56. Konomi, K., Y. Satake, S. Shimmura, K. Tsubota and J. Shimazaki (2013). “Long-term results of amniotic membrane transplantation for partial limbal deficiency.” Cornea 32(8): 1110-1115.
57. Kawakita, T., F. Kawabata, T. Tsuji, M. Kawashima, S. Shimmura and K. Tsubota (2013). “Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial.” Biomed Res 34(5): 215-220.
58. Kawai, M., Y. Ogawa, S. Shimmura, S. Ohta, T. Suzuki, N. Kawamura, M. Kuwana, Y. Kawakami and K. Tsubota (2013). “Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease.” Sci Rep 3: 2455.
59. Inagaki, E., S. Hatou, S. Yoshida, H. Miyashita, K. Tsubota and S. Shimmura (2013). “Expression and distribution of claudin subtypes in human corneal endothelium.” Invest Ophthalmol Vis Sci 54(12): 7258-7265.
60. Hirayama, M., M. Ogawa, M. Oshima, Y. Sekine, K. Ishida, K. Yamashita, K. Ikeda, S. Shimmura, T. Kawakita, K. Tsubota and T. Tsuji (2013). “Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ.” Nat Commun 4: 2497.
61. Higa, K., N. Kato, S. Yoshida, Y. Ogawa, J. Shimazaki, K. Tsubota and S. Shimmura (2013). “Aquaporin 1-positive stromal niche-like cells directly interact with N-cadherin-positive clusters in the basal limbal epithelium.” Stem Cell Res 10(2): 147-155.
62. Hatou, S., S. Yoshida, K. Higa, H. Miyashita, E. Inagaki, H. Okano, K. Tsubota and S. Shimmura (2013). “Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/beta-catenin signaling.” Stem Cells Dev 22(5): 828-839.
63. Hatou, S., K. Higa, E. Inagaki, S. Yoshida, E. Kimura, R. Hayashi, M. Tsujikawa, K. Tsubota, K. Nishida and S. Shimmura (2013). “Validation of Na,K-ATPase pump function of corneal endothelial cells for corneal regenerative medicine.” Tissue Eng Part C Methods 19(12): 901-910.
64. Yaguchi, S., Y. Ogawa, S. Shimmura, S. Hatou, S. Nakamura, T. Inaba, T. Imada, Y. Ozawa, Y. Kawakami, S. Ishida and K. Tsubota (2012). “Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland.” Invest Ophthalmol Vis Sci 53(9): 5416-5425.
65. Uchino, Y., T. Kawakita, M. Miyazawa, T. Ishii, H. Onouchi, K. Yasuda, Y. Ogawa, S. Shimmura, N. Ishii and K. Tsubota (2012). “Oxidative stress induced inflammation initiates functional decline of tear production.” PLoS One 7(10): e45805.
66. Tatematsu, Y., Y. Ogawa, S. Shimmura, M. Dogru, S. Yaguchi, T. Nagai, K. Yamazaki, K. Kameyama, S. Okamoto, Y. Kawakami and K. Tsubota (2012). “Mucosal microvilli in dry eye patients with chronic GVHD.” Bone Marrow Transplant 47(3): 416-425.
67. Ozeki, N., K. Yuki, D. Shiba, S. Shimmura, D. Murat and K. Tsubota (2012). “Intraocular pressure elevation after Descemet’s stripping endothelial keratoplasty.” Jpn J Ophthalmol 56(4): 307-311.
68. Omoto, M., S. Yoshida, H. Miyashita, T. Kawakita, K. Yoshida, A. Kishino, T. Kimura, S. Shibata, K. Tsubota, H. Okano and S. Shimmura (2012). “The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model.” PLoS One 7(11): e47716.
69. Kobayashi, S., T. Kawakita, M. Kawashima, N. Okada, K. Mishima, I. Saito, M. Ito, S. Shimmura and K. Tsubota (2012). “Characterization of cultivated murine lacrimal gland epithelial cells.” Mol Vis 18: 1271-1277.
70. Kawashima, M., T. Kawakita, T. Inaba, N. Okada, M. Ito, S. Shimmura, M. Watanabe, K. Shinmura and K. Tsubota (2012). “Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice.” PLoS One 7(3): e33148.
71. Kamoi, M., Y. Ogawa, S. Nakamura, M. Dogru, T. Nagai, H. Obata, M. Ito, M. Kaido, T. Kawakita, Y. Okada, Y. Kawakami, S. Shimmura and K. Tsubota (2012). “Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren’s type dry eye in visual display terminal users.” PLoS One 7(9): e43688.
72. Yoshida, S., M. Yasuda, H. Miyashita, Y. Ogawa, T. Yoshida, Y. Matsuzaki, K. Tsubota, H. Okano and S. Shimmura (2011). “Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells.” PLoS One 6(12): e28856.
73. Uchino, Y., S. Shimmura, T. Yamaguchi, T. Kawakita, Y. Matsumoto, K. Negishi and K. Tsubota (2011). “Comparison of corneal thickness and haze in DSAEK and penetrating keratoplasty.” Cornea 30(3): 287-290.
74. Shimazaki, J., S. Den, M. Omoto, Y. Satake, S. Shimmura and K. Tsubota (2011). “Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation.” Am J Ophthalmol 152(1): 33-39 e31.
75. Okada, N., T. Kawakita, K. Mishima, I. Saito, H. Miyashita, S. Yoshida, S. Shimmura and K. Tsubota (2011). “Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro.” Invest Ophthalmol Vis Sci 52(6): 2905-2910.
76. Niibe, K., Y. Kawamura, D. Araki, S. Morikawa, K. Miura, S. Suzuki, S. Shimmura, T. Sunabori, Y. Mabuchi, Y. Nagai, T. Nakagawa, H. Okano and Y. Matsuzaki (2011). “Purified mesenchymal stem cells are an efficient source for iPS cell induction.” PLoS One 6(3): e17610.
77. Kubota, M., S. Shimmura, S. Kubota, H. Miyashita, N. Kato, K. Noda, Y. Ozawa, T. Usui, S. Ishida, K. Umezawa, T. Kurihara and K. Tsubota (2011). “Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.” Invest Ophthalmol Vis Sci 52(1): 427-433.
78. Kawashima, M., T. Kawakita, Y. Maida, M. Kamoi, Y. Ogawa, S. Shimmura, K. Masutomi and K. Tsubota (2011). “Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients.” Mol Vis 17: 1397-1404.
79. Kawakita, T., K. Higa, S. Shimmura, M. Tomita, K. Tsubota and J. Shimazaki (2011). “Fate of corneal epithelial cells separated from limbus in vivo.” Invest Ophthalmol Vis Sci 52(11): 8132-8137.
80. Inagaki, E., Y. Ogawa, Y. Matsumoto, T. Kawakita, S. Shimmura and K. Tsubota (2011). “Four cases of corneal perforation in patients with chronic graft-versus-host disease.” Mol Vis 17: 598-606.
81. Higa, K., N. Takeshima, F. Moro, T. Kawakita, M. Kawashima, M. Demura, J. Shimazaki, T. Asakura, K. Tsubota and S. Shimmura (2011). “Porous Silk Fibroin Film as a Transparent Carrier for Cultivated Corneal Epithelial Sheets.” J Biomater Sci 22: 2261-2276.
82. Hatou, S., S. Shimmura, J. Shimazaki, T. Usui, S. Amano, H. Yokogawa, A. Kobayashi, X. Zheng, A. Shiraishi, Y. Ohashi, T. Inatomi and K. Tsubota (2011). “Mathematical projection model of visual loss due to fuchs corneal dystrophy.” Invest Ophthalmol Vis Sci 52(11): 7888-7893.
83. Hatou, S., M. Dogru, O. M. Ibrahim, T. Wakamatsu, E. A. Sato, S. Shimmura, K. Negishi and K. Tsubota (2011). “The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in Mooren’s ulcer.” Invest Ophthalmol Vis Sci 52(9): 6680-6689.
84. Yamaguchi, T., K. Negishi, K. Yamaguchi, M. Dogru, Y. Uchino, S. Shimmura and K. Tsubota (2010). “Comparison of anterior and posterior corneal surface irregularity in Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty.” Cornea 29(10): 1086-1090.
85. Omoto, M., S. Shimmura, S. Hatou, Y. Ichihashi, T. Kawakita and K. Tsubota (2010). “Simultaneous deep anterior lamellar keratoplasty and limbal allograft in bilateral limbal stem cell deficiency.” Jpn J Ophthalmol 54(6): 537-543.
86. Kubota, M., S. Shimmura, H. Miyashita, M. Kawashima, T. Kawakita and K. Tsubota (2010). “The anti-oxidative role of ABCG2 in corneal epithelial cells.” Invest Ophthalmol Vis Sci 51(11): 5617-5622.
87. Kawashima, M., T. Kawakita, N. Okada, Y. Ogawa, D. Murat, S. Nakamura, H. Nakashima, S. Shimmura, K. Shinmura and K. Tsubota (2010). “Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats.” Biochem Biophys Res Commun 397(4): 724-728.
88. Yuki, K., S. Shimmura, D. Shiba and K. Tsubota (2009). “End-stage glaucoma in Stevens-Johnson syndrome.” Jpn J Ophthalmol 53(1): 68-70.
89. Yamaguchi, T., K. Negishi, K. Yamaguchi, D. Murat, Y. Uchino, S. Shimmura and K. Tsubota (2009). “Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty.” J Cataract Refract Surg 35(4): 688-694.
90. Omoto, M., H. Miyashita, S. Shimmura, K. Higa, T. Kawakita, S. Yoshida, M. McGrogan, J. Shimazaki and K. Tsubota (2009). “The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets.” Invest Ophthalmol Vis Sci 50(5): 2109-2115.
91. Ogawa, Y., S. Shimmura, T. Kawakita, S. Yoshida, Y. Kawakami and K. Tsubota (2009). “Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.” Am J Pathol 175(6): 2372-2381.
92. Morikawa, S., Y. Mabuchi, K. Niibe, S. Suzuki, N. Nagoshi, T. Sunabori, S. Shimmura, Y. Nagai, T. Nakagawa, H. Okano and Y. Matsuzaki (2009). “Development of mesenchymal stem cells partially originate from the neural crest.” Biochem Biophys Res Commun 379(4): 1114-1119.
93. Morikawa, S., Y. Mabuchi, Y. Kubota, Y. Nagai, K. Niibe, E. Hiratsu, S. Suzuki, C. Miyauchi-Hara, N. Nagoshi, T. Sunabori, S. Shimmura, A. Miyawaki, T. Nakagawa, T. Suda, H. Okano and Y. Matsuzaki (2009). “Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow.” J Exp Med 206(11): 2483-2496.
94. Ma, X., S. Shimmura, H. Miyashita, S. Yoshida, M. Kubota, T. Kawakita and K. Tsubota (2009). “Long-term culture and growth kinetics of murine corneal epithelial cells expanded from single corneas.” Invest Ophthalmol Vis Sci 50(6): 2716-2721.
95. Kurihara, T., M. Omoto, K. Noda, M. Ebinuma, S. Kubota, H. Koizumi, S. Yoshida, Y. Ozawa, S. Shimmura, S. Ishida and K. Tsubota (2009). “Retinal phototoxicity in a novel murine model of intraocular lens implantation.” Mol Vis 15: 2751-2761.
96. Kawashima, M., T. Kawakita, S. Yoshida, S. Shimmura and K. Tsubota (2009). “Nucleostemin as a possible progenitor marker of corneal epithelial cells.” Mol Vis 15: 1162-1168.
97. Kawashima, M., T. Kawakita, S. Shimmura, K. Tsubota and J. Shimazaki (2009). “Characteristics of traumatic globe rupture after keratoplasty.” Ophthalmology 116(11): 2072-2076.
98. Kawakita, T., S. Shimmura, K. Higa, E. M. Espana, H. He, J. Shimazaki, K. Tsubota and S. C. Tseng (2009). “Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets.” Invest Ophthalmol Vis Sci 50(10): 4611-4617.
99. Higa, K., S. Shimmura, H. Miyashita, N. Kato, Y. Ogawa, T. Kawakita, J. Shimazaki and K. Tsubota (2009). “N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro.” Invest Ophthalmol Vis Sci 50(10): 4640-4645.
100. Yuki, K., S. Shimmura, D. Shiba and K. Tsubota (2008). “Trabeculotomy for the treatment of glaucoma after Descemet stripping endothelial keratoplasty.” Br J Ophthalmol 92(9): 1299-1300.
101. Uchino, M., D. A. Schaumberg, M. Dogru, Y. Uchino, K. Fukagawa, S. Shimmura, T. Satoh, T. Takebayashi and K. Tsubota (2008). “Prevalence of dry eye disease among Japanese visual display terminal users.” Ophthalmology 115(11): 1982-1988.
102. Uchino, M., M. Dogru, Y. Uchino, K. Fukagawa, S. Shimmura, T. Takebayashi, D. A. Schaumberg and K. Tsubota (2008). “Japan Ministry of Health study on prevalence of dry eye disease among Japanese high school students.” Am J Ophthalmol 146(6): 925-929 e922.
103. Tomita, M., S. Shimmura, K. Tsubota and J. Shimazaki (2008). “Postkeratoplasty atopic sclerokeratitis in keratoconus patients.” Ophthalmology 115(5): 851-856.
104. Ozawa, Y., K. Nakao, T. Kurihara, T. Shimazaki, S. Shimmura, S. Ishida, A. Yoshimura, K. Tsubota and H. Okano (2008). “Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.” J Biol Chem 283(36): 24561-24570.
105. Mochimaru, H., T. Usui, T. Yaguchi, Y. Nagahama, G. Hasegawa, Y. Usui, S. Shimmura, K. Tsubota, S. Amano, Y. Kawakami and S. Ishida (2008). “Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.” Invest Ophthalmol Vis Sci 49(5): 2172-2177.
106. Miyashita, H., S. Shimmura, K. Higa, S. Yoshida, T. Kawakita, J. Shimazaki and K. Tsubota (2008). “A novel NIH/3T3 duplex feeder system to engineer corneal epithelial sheets with enhanced cytokeratin 15-positive progenitor populations.” Tissue Eng Part A 14(7): 1275-1282.
107. Kawakita, T., S. Shimmura, A. Hornia, K. Higa and S. C. Tseng (2008). “Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell.” J Cell Mol Med 12(4): 1303-1316.
108. Igarashi, T., S. Shimmura, S. Yoshida, M. Tonogi, N. Shinozaki and G. Y. Yamane (2008). “Isolation of oral epithelial progenitors using collagen IV.” Oral Dis 14(5): 413-418.
109. Uchino, Y., S. Shimmura, H. Miyashita, T. Taguchi, H. Kobayashi, J. Shimazaki, J. Tanaka and K. Tsubota (2007). “Amniotic membrane immobilized poly(vinyl alcohol) hybrid polymer as an artificial cornea scaffold that supports a stratified and differentiated corneal epithelium.” J Biomed Mater Res B Appl Biomater 81(1): 201-206.
110. Shimazaki, J., K. Higa, F. Morito, M. Dogru, T. Kawakita, Y. Satake, S. Shimmura and K. Tsubota (2007). “Factors influencing outcomes in cultivated limbal epithelial transplantation for chronic cicatricial ocular surface disorders.” Am J Ophthalmol 143(6): 945-953.
111. Ozawa, Y., K. Nakao, T. Shimazaki, S. Shimmura, T. Kurihara, S. Ishida, A. Yoshimura, K. Tsubota and H. Okano (2007). “SOCS3 is required to temporally fine-tune photoreceptor cell differentiation.” Dev Biol 303(2): 591-600.
112. Ogawa, Y., M. S. Razzaque, K. Kameyama, G. Hasegawa, S. Shimmura, M. Kawai, S. Okamoto, Y. Ikeda, K. Tsubota, Y. Kawakami and M. Kuwana (2007). “Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD.” Invest Ophthalmol Vis Sci 48(3): 1079-1086.
113. Miyashita, H., K. Higa, N. Kato, T. Kawakita, S. Yoshida, K. Tsubota and S. Shimmura (2007). “Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro.” Invest Ophthalmol Vis Sci 48(8): 3586-3593.
114. Matsumoto, Y., M. Dogru, E. A. Sato, Y. Katono, Y. Uchino, S. Shimmura and K. Tsubota (2007). “The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis.” Mol Vis 13: 1319-1326.
115. Kato, N., S. Shimmura, T. Kawakita, H. Miyashita, Y. Ogawa, S. Yoshida, K. Higa, H. Okano and K. Tsubota (2007). “Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium.” Invest Ophthalmol Vis Sci 48(4): 1511-1517.
116. Higuchi, A., R. Ueno, S. Shimmura, M. Suematsu, M. Dogru and K. Tsubota (2007). “Albumin rescues ocular epithelial cells from cell death in dry eye.” Curr Eye Res 32(2): 83-88.
117. Higa, K., S. Shimmura, N. Kato, T. Kawakita, H. Miyashita, Y. Itabashi, K. Fukuda, J. Shimazaki and K. Tsubota (2007). “Proliferation and Differentiation of Transplantable Rabbit Epithelial Sheets Engineered with or without an Amniotic Membrane Carrier.” Invest Ophthalmol Vis Sci 48(2): 597-604.
118. Dogru, M., N. Kato, Y. Matsumoto, Y. Tanaka, N. Akabane, S. Shimmura, K. Tsubota and J. Shimazaki (2007). “Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.” Curr Eye Res 32(10): 863-870.
119. Den, S., S. Shimmura, K. Tsubota and J. Shimazaki (2007). “Impact of the descemet membrane perforation on surgical outcomes after deep lamellar keratoplasty.” Am J Ophthalmol 143(5): 750-754.
120. Yoshida, S., S. Shimmura, N. Nagoshi, K. Fukuda, Y. Matsuzaki, H. Okano and K. Tsubota (2006). “Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea.” Stem Cells 24(12): 2714-2722.
121. Yoshida, S., S. Shimmura, T. Kawakita, H. Miyashita, S. Den, J. Shimazaki and K. Tsubota (2006). “Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces.” Invest Ophthalmol Vis Sci 47(11): 4780-4786.
122. Uchino, Y., E. Goto, Y. Takano, M. Dogru, N. Shinozaki, S. Shimmura, Y. Yagi, K. Tsubota and J. Shimazaki (2006). “Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency.” Ophthalmology 113(7): 1098-1101.
123. Tomita, M., S. Shimmura, K. Tsubota and J. Shimazaki (2006). “Dacryoadenitis associated with Acanthamoeba keratitis.” Arch Ophthalmol 124(9): 1239-1242.
124. Shimmura, S., H. Miyashita, Y. Uchino, T. Taguchi, H. Kobayashi, J. Shimazaki, J. Tanaka and K. Tsubota (2006). “Microkeratome assisted deep lamellar keratoprosthesis.” Br J Ophthalmol 90(7): 826-829.
125. Shimmura, S., H. Miyashita, K. Higa, S. Yoshida, J. Shimazaki and K. Tsubota (2006). “Proteomic analysis of soluble factors secreted by limbal fibroblasts.” Mol Vis 12: 478-484.
126. Shimazaki, J., K. Konomi, S. Shimmura and K. Tsubota (2006). “Ocular surface reconstruction for thermal burns caused by fireworks.” Cornea 25(2): 139-145.
127. Miyashita, H., S. Shimmura, H. Kobayashi, T. Taguchi, N. Asano-Kato, Y. Uchino, M. Kato, J. Shimazaki, J. Tanaka and K. Tsubota (2006). “Collagen-immobilized poly(vinyl alcohol) as an artificial cornea scaffold that supports a stratified corneal epithelium.” J Biomed Mater Res B Appl Biomater 76(1): 56-63.
128. Maruyama-Hosoi, F., J. Shimazaki, S. Shimmura and K. Tsubota (2006). “Changes Observed in Keratolimbal Allograft.” Cornea 25(4): 377-382.
129. Kawashima, M., T. Kawakita, S. Den, S. Shimmura, K. Tsubota and J. Shimazaki (2006). “Comparison of deep lamellar keratoplasty and penetrating keratoplasty for lattice and macular corneal dystrophies.” Am J Ophthalmol 142(2): 304-309.
130. Higuchi, A., S. Shimmura, T. Takeuchi, M. Suematsu and K. Tsubota (2006). “Elucidation of apoptosis induced by serum deprivation in cultured conjunctival epithelial cells.” Br J Ophthalmol 90(6): 760-764.
131. Higa, K., S. Shimmura, J. Shimazaki and K. Tsubota (2006). “Ocular surface epithelial cells up-regulate HLA-G when expanded in vitro on amniotic membrane substrates.” Cornea 25(6): 715-721.
132. Den, S., K. Shimizu, T. Ikeda, K. Tsubota, S. Shimmura and J. Shimazaki (2006). “Association between meibomian gland changes and aging, sex, or tear function.” Cornea 25(6): 651-655.
133. Den, S., M. Dogru, N. Kato, Y. Tanaka, S. Shimmura and J. Shimazaki (2006). “Disseminated keratoconjunctival epitheliopathy in a patient with systemic lupus erythematosus.” Br J Ophthalmol 90(8): 1068-1070.
134. Yoshida, S., S. Shimmura, J. Shimazaki, N. Shinozaki and K. Tsubota (2005). “Serum-free spheroid culture of mouse corneal keratocytes.” Invest Ophthalmol Vis Sci 46(5): 1653-1658.
135. Shimmura, S., J. Shimazaki, M. Omoto, A. Teruya, M. Ishioka and K. Tsubota (2005). “Deep lamellar keratoplasty (DLKP) in keratoconus patients using viscoadaptive viscoelastics.” Cornea 24(2): 178-181.
136. Shimmura, S., M. Omoto, S. Den, H. Bissen-Miyajima, K. Tsubota and J. Shimazaki (2005). “Microkeratome-assisted phacoemulsification.” J Cataract Refract Surg 31(9): 1699-1701.
137. Shimmura, S., H. Miyashita, K. Konomi, N. Shinozaki, T. Taguchi, H. Kobayashi, J. Shimazaki, J. Tanaka and K. Tsubota (2005). “Transplantation of corneal endothelium with Descemet’s membrane using a hyroxyethyl methacrylate polymer as a carrier.” Br J Ophthalmol 89(2): 134-137.
138. Higa, K., S. Shimmura, J. Shimazaki and K. Tsubota (2005). “Hyaluronic acid-CD44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma.” Cornea 24(2): 206-212.
139. Higa, K., S. Shimmura, H. Miyashita, J. Shimazaki and K. Tsubota (2005). “Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells.” Exp Eye Res 81(2): 218-223.
140. Dogru, M., N. Asano-Kato, M. Tanaka, A. Igarashi, S. Shimmura, J. Shimazaki, N. Okada, Y. Takano, K. Fukagawa, K. Tsubota and H. Fujishima (2005). “Ocular Surface and MUC5AC Alterations in Atopic Patients with Corneal Shield Ulcers.” Curr Eye Res 30(10): 897-908.
141. Shimmura, S., K. Tadano and K. Tsubota (2004). “UV dose-dependent caspase activation in a corneal epithelial cell line.” Curr Eye Res 28(2): 85-92.
142. Shimmura, S., M. Ando, M. Ishioka, J. Shimazaki and K. Tsubota (2004). “Same-size donor corneas for myopic keratoconus.” Cornea 23(4): 345-349.
143. Shimazaki, J., N. Shinozaki, S. Shimmura, E. J. Holland and K. Tsubota (2004). “Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation.” Transplantation 78(2): 216-220.
144. Shimazaki, J., S. Shimmura and K. Tsubota (2004). “Donor source affects the outcome of ocular surface reconstruction in chemical or thermal burns of the cornea.” Ophthalmology 111(1): 38-44.
145. Konomi, K., J. Shimazaki, S. Shimmura, N. Akabane, E. Goto and K. Tsubota (2004). “Efficacy of core vitrectomy preceding triple corneal procedure.” Br J Ophthalmol 88(8): 1023-1025.
146. Kobayashi, H., M. Kato, T. Taguchi, T. Ikoma, H. Miyashita, S. Shimmura, K. Tsubota and J. Tanaka (2004). “Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea ” Mater Sci Eng C 24: 729-735.
147. Dogru, M., B. Kaderli, O. Gelisken, A. Yucel, R. Avci, E. Goto, S. Shimmura, J. Shimazaki and K. Tsubota (2004). “Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus.” Am J Ophthalmol 138(3): 381-388.
148. Bissen-Miyajima, H., K. Nakamura, M. Kaido, S. Shimmura and K. Tsubota (2004). “Role of the endothelial pump in flap adhesion after laser in situ keratomileusis.” J Cataract Refract Surg 30(9): 1989-1992.
149. Shimmura, S., R. Ueno, Y. Matsumoto, E. Goto, A. Higuchi, J. Shimazaki and K. Tsubota (2003). “Albumin as a tear supplement in the treatment of severe dry eye.” Br J Ophthalmol 87(10): 1279-1283.
150. Shimmura, S., J. Shimazaki and K. Tsubota (2003). “Therapeutic deep lamellar keratoplasty for cornea perforation.” Am J Ophthalmol 135(6): 896-897.
151. Shimmura, S., Y. Ohashi, H. Shiroma, J. Shimazaki and K. Tsubota (2003). “Corneal opacity and cataract: triple procedure versus secondary approach.” Cornea 22(3): 234-238.
152. Shimmura, S., R. Igarashi, H. Yaguchi, Y. Ohashi, J. Shimazaki and K. Tsubota (2003). “Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers.” Am J Ophthalmol 135(5): 613-619.
153. Shimmura, S., C. J. Doillon, M. Griffith, M. Nakamura, E. Gagnon, A. Usui, N. Shinozaki and K. Tsubota (2003). “Collagen-poly(N-isopropylacrylamide)-based membranes for corneal stroma scaffolds.” Cornea 22(7 Suppl): S81-88.
154. Shimazaki, J., K. Kosaka, S. Shimmura and K. Tsubota (2003). “Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium.” Ophthalmology 110(1): 119-124.
155. Mori, A., J. Shimazaki, S. Shimmura, H. Fujishima, Y. Oguchi and K. Tsubota (2003). “Disposable eyelid-warming device for the treatment of meibomian gland dysfunction.” Jpn J Ophthalmol 47(6): 578-586.
156. Asano-Kato, N., I. Toda, S. Shimmura, T. Noda-Tsuruya, K. Fukagawa, M. Yoshinaga, A. Matsukawa and K. Tsubota (2003). “Detection of neutrophils and possible involvement of interleukin-8 in diffuse lamellar keratitis after laser in situ keratomileusis.” J Cataract Refract Surg 29(10): 1996-2000.
157. Tsubota, K., S. Shimmura, N. Shinozaki, E. J. Holland and J. Shimazaki (2002). “Clinical application of living-related conjunctival-limbal allograft.” Am J Ophthalmol 133: 134-135.
158. Takahashi, H., A. Sakamoto, R. Takahashi, T. Ohmura, S. Shimmura and K. Ohara (2002). “Free radicals in phacoemulsification and aspiration procedures.” Arch Ophthalmol 120(10): 1348-1352.
159. Shimazaki, J., S. Shimmura and K. Tsubota (2002). “Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).” Cornea 21(2): 177-180.
160. Shimazaki, J., S. Shimmura, M. Ishioka and K. Tsubota (2002). “Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty(1).” Am J Ophthalmol 134(2): 159-165.
161. Shimazaki, J., M. Aiba, E. Goto, N. Kato, S. Shimmura and K. Tsubota (2002). “Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders.” Ophthalmology 109(7): 1285-1290.
162. Higuchi, A., S. Shimmura, M. Ishii, H. Aburatani and K. Tsubota (2002). “Serum- and serum deprivation-induced transcriptional profiles of cultured conjunctival epithelial cells.” Adv Exp Med Biol 506(Pt A): 673-676.
163. Goto, E., J. Shimazaki, Y. Monden, Y. Takano, Y. Yagi, S. Shimmura and K. Tsubota (2002). “Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction.” Ophthalmology 109(11): 2030-2035.
164. Goto, E., Y. Monden, Y. Takano, A. Mori, S. Shimmura, J. Shimazaki and K. Tsubota (2002). “Treatment of non-inflamed obstructive meibomian gland dysfunction by an infrared warm compression device.” Br J Ophthalmol 86(12): 1403-1407.
165. Shimmura, S., J. Shimazaki, Y. Ohashi and K. Tsubota (2001). “Anti-inflammatory effects of amniotic membrane transplantation in ocular surface disorders.” Cornea 20: 408-413.
166. Shimazaki, J., F. Maruyama, S. Shimmura, H. Fujishima and K. Tsubota (2001). “Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty.” Cornea 20(2): 149-152.
167. Miyoshi, T., K. Fukagawa, S. Shimmura, H. Fujishima, Y. Takano, E. Takamura, K. Tsubota, H. Saito and Y. Oguchi (2001). “Interleukin-8 concentrations in conjunctival epithelium brush cytology samples correlate with neutrophil, eosinophil infiltration, and corneal damage.” Cornea 20(7): 743-747.
168. Ishioka, M., S. Shimmura, Y. Yagi and K. Tsubota (2001). “Pterygium and dry eye.” Ophthalmologica 215(3): 209-211.
169. Hanada, K., J. Shimazaki, S. Shimmura and K. Tsubota (2001). “Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera.” Am J Ophthalmol 131(3): 324-331.
170. Goto, E., S. Shimmura, J. Shimazaki and K. Tsubota (2001). “Treatment of superior limbic keratoconjunctivitis by application of autologous serum.” Cornea 20(8): 807-810.
171. Shimmura, S., K. Matsumoto, H. Yaguchi, T. Okuda, S. Miyajima, A. Negi, J. Shimazaki and K. Tsubota (2000). “Acidic electrolyzed water in the disinfection of the ocular surface.” Exp Eye Res 70: 1-6.
172. Shimmura, S., M. Ishioka, K. Hanada, J. Shimazaki and K. Tsubota (2000). “Telomerase activity and p53 expression in pterygia.” Invest Ophthalmol Vis Sci 41(6): 1364-1369.
173. Shimmura, S., M. Ando, J. Shimazaki and K. Tsubota (2000). “Complications with one-piece lamellar kerato-limbal grafts for simultaneous limbal and corneal pathologies.” Cornea 19(4): 439-442.
174. Shimazaki, S., S. Shimmura, H. Fujishima and K. Tsubota (2000). “Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome.” Ophthalmology 107: 1518-1523.
175. Shimazaki, J., K. Hanada, Y. Yagi, J. Yamagami, M. Ishioka, S. Shimmura and K. Tsubota (2000). “Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol v 0. 12% unoprostone.” Br J Ophthalmol 84(11): 1250-1254.
176. Nakamura, K., H. Bissen-Miyajima, S. Shimmura and K. Tsubota (2000). “Clinical application of Er:YAG laser for the treatment of pterygium.” Ophthalmic Surg Lasers 31(1): 8-12.
177. Ishioka, M., J. Shimazaki, J. Yamagami, H. Fujishima, S. Shimmura and K. Tsubota (2000). “Trabeculectomy with mitomycin C for post-keratoplasty glaucoma.” Br J Ophthalmol 84: 714-717.
178. Fukagawa, K., T. Nakajima, H. Saito, K. Tsubota, S. Shimmura, M. Natori and K. Hirai (2000). “IL-4 induces eotaxin production in corneal keratocytes but not in epithelial cells.” Int Arch Allergy Immunol 121: 144-150.
179. Tsubota, K., Y. Satake, M. Kaido, N. Shinozaki, S. Shimmura, H. Bissen-Miyajima and J. Shimazaki (1999). “Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation.” N Engl J Med 340(22): 1697-1703.
180. Tsubota, K., Y. Monden, Y. Yagi, E. Goto and S. Shimmura (1999). “New treatement of dry eye. The effect of calcium ointment through eyelid skin delivery.” Br J Ophthalmol 83: 767-770.
181. Tsubota, K., M. Kaido, Y. Yagi, T. Fujihara and S. Shimmura (1999). “Diseases associated with ocular surface abnormalities: The importance of reflex tearing.” Br J Ophthalmol 83: 89-91.
182. Tsubota, K., E. Goto, S. Shimmura and J. Shimazaki (1999). “Treatment of persistent corneal epithelial defect by autologous serum application.” Ophthalmology 106: 1984-1989.
183. Tsubota, K., E. Goto, H. Fujita, M. Ono, H. Inoue, I. Saito and S. Shimmura (1999). “Treatment of dry eye by autologus serum application in Sjogren’s Syndrome.” Br J Ophthalmol 83: 390-395.
184. Tsubota, K., K. Fukagawa, T. Fujihara, S. Shimmura, I. Saito, K. Saito and T. Takeuchi (1999). “Regulation of HLA DR expression in human conjunctival epithelium.” Invest Ophthalmol Vis Sci 40: 28-34.
185. Takano, Y., K. Fukagawa, S. Shimmura, K. Tsubota, Y. Oguchi and H. Saito (1999). “IL-4 regulates chemokine production induced by TNF-a in keratocytes and corneal epithelial cells.” Br J Ophthalmol 83: 1074-1076.
186. Shimmura, S., J. Shimazaki and K. Tsubota (1999). “Results of a population -based questionnaire on the symptoms and lifestyles associated with dry eye.” Cornea 18: 408-411.
187. Shimmura, S., T. Masumizu, K. Urayama, J. Shimazaki, H. Bissen-Miyajima and K. Tsubota (1999). “Excimer laser-induced hydroxyl radical formation and keratocyte death in vitro.” Invest Ophthalmol Vis Sci 40: 1245-1249.
188. Shimazaki, J., S. Shimmura, K. Yamato and K. Tsubota (1999). “Morphology and barrier function of the corneal epithelium following penetrating keratoplasty: association with original diseases, tear function, and suture removal.” Cornea 18: 559-564.
189. Shimazaki, J., M. Kaido, N. Shinozaki, S. Shimmura, B. Munkhbat, M. Hagihara, K. Tsuji and K. Tsubota (1999). “Evidence of long-term survival of donor-derived cells after limbal allograft transplantation.” Invest Ophthalmol Vis Sci 40: 1664-1668.
190. Nakamura, K., H. Bissen-Miyajima, H. Arai, I. Toda, Y. Hori, S. Shimmura and K. Tsubota (1999). “Iatrogenic cataract after laser-assisted in situ keratomileusis.” Am J Ophthalmol 128: 507-509.
191. Fukagawa, K., T. Nakajima, K. Tsubota, S. Shimmura, H. Saito and K. Hirai (1999). “Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage.” J Allergy Clin Immunol 103: 1220-1221.
192. Bissen-Miyajima, H., S. Shimmura and K. Tsubota (1999). “Thermal effect on corneal incisions with different ultrasonic tips.” J Cataract Refract Surg 25: 60-64.
193. Shimmura, S., N. Shinozaki, K. Fukagawa, J. Shimazaki and K. Tsubota (1998). “Real-time telemedicine in the clinical assessment of the ocular surface.” Am J Ophthalmol 125: 388-390.
194. Shimmura, S., M. Shimoyama, M. Hojo, K. Urayama and K. Tsubota (1998). “Reoxygenation injury in a cultured corneal epithelial cell line protected by the uptake of lactoferrin.” Invest Ophthalmol Vis Sci 39: 1346-1351.
195. Shimmura, S., K. Matsumoto, E. Goto, K. Saito, T. Takeuchi, S. Miyajima, A. Negi and K. Tsubota (1998). “Lecithin-bound superoxide dismutase in the prevention of neutrophil-induced damage of corneal tissue.” Invest Ophthalmol Vis Sci 39: 30-35.
196. Shimmura, S., E. Goto, J. Shimazaki and K. Tsubota (1998). “Viscosity-dependent fluid dynamics of eyedrops on the ocular surface.” Am J Ophthalmol 125(3): 386-388.
197. Shimazaki, J., H.-Y. Yang, S. Shimmura and K. Tsubota (1998). “Terrien’s marginal degeneration associated with erythema elevatum diutinum.” Cornea 17: 342-344.
198. Shimazaki, J., S. Shimmura and K. Tsubota (1998). “Intraoperative versus postoperative suture adjustment after penetrating keratoplasty.” Cornea 17: 590-594.
199. Shimazaki, J., E. Goto, M. Ono, S. Shimmura and K. Tsubota (1998). “Meibomian gland dysfunction in patients with Sjogren syndrome.” Ophthalmology 105: 1485-1488.
200. Shimoyama, M., S. Shimmura, K. Tsubota and Y. Oguchi (1997). “Suppression of nuclear factor kappa B and CD 18 mediated leukocyte adhesion to the corneal endothelium by dexamethasone.” Invest Ophthalmol Vis Sci 38(11): 2427-2431.
201. Shimmura, S., H.-Y. Yang, H. Bissen-Miyajima, J. Shimazaki and K. Tsubota (1997). “Posterior corneal protrusion following PRK.” Cornea 16: 686-688.
202. Shimmura, S. and K. Tsubota (1997). “Ultraviolet B-induced mitochondrial dysfunction is associated with decreased cell detachment of corneal epithelial cells in vitro.” Invest Ophthalmol Vis Sci 38(3): 620-626.
203. Shimmura, S., N. Shinozaki, K. Fukagawa and K. Tsubota (1997). “Telemedicine in the follow-up of corneal transplant patients.” J Telemed Telecare 3(4): 227-228.
204. Fukagawa, K., H. Saito, K. Tsubota, S. Shimmura, H. Tachimoto, A. Akasawa and Y. Oguchi (1997). “RANTES production in a conjunctival epithelial cell line.” Cornea 16: 564-570.
205. Shimmura, S., M. Suematsu, M. Shimoyama, K. Tsubota, Y. Oguchi and Y. Ishimura (1996). “Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells: the protective effects of lactoferrin.” Exp Eye Res 63(5): 519-526.
206. Shimmura, S., M. Ono, K. Shinozaki, I. Toda, E. Takamura, Y. Mashima and K. Tsubota (1995). “Sodium hyaluronate eyedrops in the treatment of dry eyes.” Br J Ophthalmol 79(11): 1007-1011.
207. Shimmura, S., K. Tsubota, Y. Oguchi, D. Fukumura, M. Suematsu and M. Tsuchiya (1992). “Oxiradical-dependent photoemission induced by a phacoemulsification probe.” Invest Ophthalmol Vis Sci 33(10): 2904-2907.