1. Shimizu S, Sato S, Taniguchi H, et al. Observation of Chronic Graft-Versus-Host Disease Mouse Model Cornea with In Vivo Confocal Microscopy. Diagnostics (Basel) 2021;11.

2. Rusch RM, Ogawa Y, Sato S, et al. MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation. Int J Mol Sci 2021;22.

3. Inagaki E, Hatou S, Arai E, et al. The Ocular Anterior Chamber as a Novel in Vivo Tumorigenicity Test for Preclinical Safety Studies. Stem cells translational medicine 2021;in submission.

4. Hatou S, Sayano T, Higa K, et al. Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model. Stem cell research 2021;55:102497.

5. Yamazaki R, Nejima R, Ichihashi Y, Miyata K, Tsubota K, Shimmura S. Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy. Jpn J Ophthalmol 2020;64:585-590.

6. Yamane M, Sato S, Shimizu E, et al. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB J 2020;34:10778-10800.

7. Higa K, Higuchi J, Kimoto R, et al. Human corneal limbal organoids maintaining limbal stem cell niche function. Stem cell research 2020;49:102012.

8. Hata-Mizuno M, Ingaki E, Mitamura H, Uchino Y, Tsubota K, Shimmura S. Conjunctival Epithelial Ingrowth After Penetrating Keratoplasty. Cornea 2020;39:1181-1183.

9. Yamashita K, Hatou S, Uchino Y, Tsubota K, Shimmura S. Prognosis after lamellar keratoplasty for limbal dermoids using preserved corneas. Jpn J Ophthalmol 2019;63:56-64.

10. Venkatraman A, Hochart G, Bonnel D, et al. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI-H626R and TGFBI-R124C Mutations. Proteomics Clin Appl 2019;13:e1800053.

11. Fujii S, Yoshida S, Inagaki E, et al. Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells. Stem cells and development 2019;28:28-43.

12. Deng SX, Borderie V, Chan CC, et al. Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. Cornea 2019;38:364-375.

13. Yamashita K, Inagaki E, Hatou S, et al. Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord. Stem cells and development 2018;27:1097-1108.

14. Yamashita K, Hatou S, Inagaki E, Higa K, Tsubota K, Shimmura S. A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells. Scientific reports 2018;8:16868.

15. Yamane M, Ogawa Y, Mukai S, et al. Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease. Cornea 2018;37:102-108.

16. Den S, Shimmura S, Shimazaki J. Cataract surgery after deep anterior lamellar keratoplasty and penetrating keratoplasty in age- and disease-matched eyes. J Cataract Refract Surg 2018;44:496-503.

17. Yamazaki R, Yamazoe K, Yoshida S, et al. The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model. Scientific reports 2017;7:15584.

18. Shimmura-Tomita M, Shimmura S, Tsubota K, Shimazaki J. Penetrating Keratoplasty Performed by Residents Compared With an Experienced Cornea Transplant Surgeon. J Surg Educ 2017;74:258-263.

19. Miyashita H, Niwano H, Yoshida S, et al. Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model. Scientific reports 2017;7:43557.

20. Inagaki E, Hatou S, Higa K, et al. Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration. Stem cells translational medicine 2017;6:788-798.

21. Hirayama M, Ko SBH, Kawakita T, et al. Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells. NPJ Aging Mech Dis 2017;3:1.

22. Ogawa Y, Morikawa S, Okano H, et al. MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model. Elife 2016;5:e09394.

23. Ogawa A, Matsumoto Y, Yaguchi T, Shimmura S, Tsubota K. Successful treatment of Beauveria bassiana fungal keratitis with topical voriconazole. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2016;22:257-260.

24. Ishiyama S, Mori Y, Nejima R, et al. Comparison of Long-Term Outcomes of Visual Function and Endothelial Cell Survival After Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty Using Mixed-Effects Models. Cornea 2016.

25. Hirayama M, Liu Y, Kawakita T, Shimmura S, Tsubota K. Cytokeratin expression in mouse lacrimal gland germ epithelium. Exp Eye Res 2016;146:54-59.

26. Yamazoe K, Yoshida S, Yasuda M, et al. Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2. PloS one 2015;10:e0133397.

27. Yaguchi S, Ogawa Y, Kawakita T, Shimmura S, Tsubota K. Tissue Renin-Angiotensin System in Lacrimal Gland Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease. Cornea 2015;34 Suppl 11:S142-152.

28. Kawakita T, Shimmura S, Tsubota K. Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjogren Syndrome. Asia-Pacific journal of ophthalmology 2015;4:101-105.

29. Kamoshita M, Matsumoto Y, Nishimura K, et al. Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2015;21:141-143.

30. Fukui M, Ogawa Y, Shimmura S, et al. Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz’s disease. Modern rheumatology / the Japan Rheumatism Association 2015;1-7.

31. Yoshida T, Ozawa Y, Suzuki K, et al. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Molecular brain 2014;7:45.

32. Shiba D, Hatou S, Ono T, et al. Multivariable logistic regression model: a novel mathematical model that predicts visual field sensitivity from macular ganglion cell complex thickness in glaucoma. PloS one 2014;9:e104126.

33. Satake Y, Yamaguchi T, Hirayama M, et al. Ocular surface reconstruction by cultivated epithelial sheet transplantation. Cornea 2014;33 Suppl 11:S42-46.

34. Kamoshita M, Ozawa Y, Kubota S, et al. AMPK-NF-kappaB axis in the photoreceptor disorder during retinal inflammation. PloS one 2014;9:e103013.

35. Fujii S, Matsumoto Y, Fukui M, et al. Clinical backgrounds of postoperative keratoplasty patients with spontaneous wound dehiscence or gaps after suture removal. Cornea 2014;33:1320-1323.

36. Yaguchi S, Ogawa Y, Shimmura S, et al. Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PloS one 2013;8:e64724.

37. Narimatsu T, Ozawa Y, Miyake S, et al. Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice. Invest Ophthalmol Vis Sci 2013;54:4555-4562.

38. Miyashita H, Yokoo S, Yoshida S, et al. Long-term maintenance of limbal epithelial progenitor cells using rho kinase inhibitor and keratinocyte growth factor. Stem cells translational medicine 2013;2:758-765.

39. Konomi K, Satake Y, Shimmura S, Tsubota K, Shimazaki J. Long-term results of amniotic membrane transplantation for partial limbal deficiency. Cornea 2013;32:1110-1115.

40. Kawakita T, Kawabata F, Tsuji T, Kawashima M, Shimmura S, Tsubota K. Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial. Biomed Res 2013;34:215-220.

41. Kawai M, Ogawa Y, Shimmura S, et al. Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. Scientific reports 2013;3:2455.

42. Inagaki E, Hatou S, Yoshida S, Miyashita H, Tsubota K, Shimmura S. Expression and distribution of claudin subtypes in human corneal endothelium. Invest Ophthalmol Vis Sci 2013;54:7258-7265.

43. Hirayama M, Ogawa M, Oshima M, et al. Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nature communications 2013;4:2497.

44. Higa K, Kato N, Yoshida S, et al. Aquaporin 1-positive stromal niche-like cells directly interact with N-cadherin-positive clusters in the basal limbal epithelium. Stem cell research 2013;10:147-155.

45. Hatou S, Yoshida S, Higa K, et al. Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/beta-catenin signaling. Stem cells and development 2013;22:828-839.

46. Hatou S, Higa K, Inagaki E, et al. Validation of Na,K-ATPase pump function of corneal endothelial cells for corneal regenerative medicine. Tissue engineering Part C, Methods 2013;19:901-910.

47. Yaguchi S, Ogawa Y, Shimmura S, et al. Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland. Invest Ophthalmol Vis Sci 2012;53:5416-5425.

48. Uchino Y, Kawakita T, Miyazawa M, et al. Oxidative stress induced inflammation initiates functional decline of tear production. PloS one 2012;7:e45805.

49. Tatematsu Y, Ogawa Y, Shimmura S, et al. Mucosal microvilli in dry eye patients with chronic GVHD. Bone marrow transplantation 2012;47:416-425.

50. Ozeki N, Yuki K, Shiba D, Shimmura S, Murat D, Tsubota K. Intraocular pressure elevation after Descemet’s stripping endothelial keratoplasty. Jpn J Ophthalmol 2012;56:307-311.

51. Omoto M, Yoshida S, Miyashita H, et al. The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model. PloS one 2012;7:e47716.

52. Kobayashi S, Kawakita T, Kawashima M, et al. Characterization of cultivated murine lacrimal gland epithelial cells. Mol Vis 2012;18:1271-1277.

53. Kawashima M, Kawakita T, Inaba T, et al. Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice. PloS one 2012;7:e33148.

54. Kamoi M, Ogawa Y, Nakamura S, et al. Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren’s type dry eye in visual display terminal users. PloS one 2012;7:e43688.

55. Yoshida S, Yasuda M, Miyashita H, et al. Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells. PloS one 2011;6:e28856.

56. Uchino Y, Shimmura S, Yamaguchi T, et al. Comparison of corneal thickness and haze in DSAEK and penetrating keratoplasty. Cornea 2011;30:287-290.

57. Suzuki A, Matsumoto Y, Uchino Y, Kawakita T, Shimmura S, Tsubota K. [Risk factors of severe peripheral corneal ulcers]. Nihon Ganka Gakkai zasshi 2011;115:116-121.

58. Shimmura S, Hatou S. Author response: can vision loss be predicted by a mathematical model of fuchs dystrophy? Invest Ophthalmol Vis Sci 2011;52:9488.

59. Shimazaki J, Den S, Omoto M, Satake Y, Shimmura S, Tsubota K. Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation. Am J Ophthalmol 2011;152:33-39 e31.

60. Okada N, Kawakita T, Mishima K, et al. Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro. Invest Ophthalmol Vis Sci 2011;52:2905-2910.

61. Niibe K, Kawamura Y, Araki D, et al. Purified mesenchymal stem cells are an efficient source for iPS cell induction. PloS one 2011;6:e17610.

62. Kubota M, Shimmura S, Kubota S, et al. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci 2011;52:427-433.

63. Kawashima M, Kawakita T, Maida Y, et al. Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients. Mol Vis 2011;17:1397-1404.

64. Kawakita T, Higa K, Shimmura S, Tomita M, Tsubota K, Shimazaki J. Fate of corneal epithelial cells separated from limbus in vivo. Invest Ophthalmol Vis Sci 2011;52:8132-8137.

65. Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K. Four cases of corneal perforation in patients with chronic graft-versus-host disease. Mol Vis 2011;17:598-606.

66. Higa K, Takeshima N, Moro F, et al. Porous Silk Fibroin Film as a Transparent Carrier for Cultivated Corneal Epithelial Sheets. Journal of biomaterials science Polymer edition 2011;22:2261-2276.

67. Hatou S, Shimmura S, Shimazaki J, et al. Mathematical projection model of visual loss due to fuchs corneal dystrophy. Invest Ophthalmol Vis Sci 2011;52:7888-7893.

68. Hatou S, Dogru M, Ibrahim OM, et al. The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in Mooren’s ulcer. Invest Ophthalmol Vis Sci 2011;52:6680-6689.

69. Yamaguchi T, Negishi K, Yamaguchi K, et al. Comparison of anterior and posterior corneal surface irregularity in Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty. Cornea 2010;29:1086-1090.

70. Omoto M, Shimmura S, Hatou S, Ichihashi Y, Kawakita T, Tsubota K. Simultaneous deep anterior lamellar keratoplasty and limbal allograft in bilateral limbal stem cell deficiency. Jpn J Ophthalmol 2010;54:537-543.

71. Kubota M, Shimmura S, Miyashita H, Kawashima M, Kawakita T, Tsubota K. The anti-oxidative role of ABCG2 in corneal epithelial cells. Invest Ophthalmol Vis Sci 2010;51:5617-5622.

72. Kawashima M, Kawakita T, Okada N, et al. Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats. Biochem Biophys Res Commun 2010;397:724-728.

73. Yuki K, Shimmura S, Shiba D, Tsubota K. End-stage glaucoma in Stevens-Johnson syndrome. Jpn J Ophthalmol 2009;53:68-70.

74. Yamaguchi T, Negishi K, Yamaguchi K, et al. Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty. J Cataract Refract Surg 2009;35:688-694.

75. Omoto M, Miyashita H, Shimmura S, et al. The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets. Invest Ophthalmol Vis Sci 2009;50:2109-2115.

76. Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K. Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease. Am J Pathol 2009;175:2372-2381.

77. Morikawa S, Mabuchi Y, Niibe K, et al. Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun 2009;379:1114-1119.

78. Morikawa S, Mabuchi Y, Kubota Y, et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 2009;206:2483-2496.

79. Ma X, Shimmura S, Miyashita H, et al. Long-term culture and growth kinetics of murine corneal epithelial cells expanded from single corneas. Invest Ophthalmol Vis Sci 2009;50:2716-2721.

80. Kurihara T, Omoto M, Noda K, et al. Retinal phototoxicity in a novel murine model of intraocular lens implantation. Mol Vis 2009;15:2751-2761.

81. Kawashima M, Kawakita T, Yoshida S, Shimmura S, Tsubota K. Nucleostemin as a possible progenitor marker of corneal epithelial cells. Mol Vis 2009;15:1162-1168.

82. Kawashima M, Kawakita T, Shimmura S, Tsubota K, Shimazaki J. Characteristics of traumatic globe rupture after keratoplasty. Ophthalmology 2009;116:2072-2076.

83. Kawakita T, Shimmura S, Higa K, et al. Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets. Invest Ophthalmol Vis Sci 2009;50:4611-4617.

84. Higa K, Shimmura S, Miyashita H, et al. N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro. Invest Ophthalmol Vis Sci 2009;50:4640-4645.

85. Yuki K, Shimmura S, Shiba D, Tsubota K. Trabeculotomy for the treatment of glaucoma after Descemet stripping endothelial keratoplasty. Br J Ophthalmol 2008;92:1299-1300.

86. Uchino M, Schaumberg DA, Dogru M, et al. Prevalence of dry eye disease among Japanese visual display terminal users. Ophthalmology 2008;115:1982-1988.

87. Uchino M, Dogru M, Uchino Y, et al. Japan Ministry of Health study on prevalence of dry eye disease among Japanese high school students. Am J Ophthalmol 2008;146:925-929 e922.

88. Tomita M, Shimmura S, Tsubota K, Shimazaki J. Postkeratoplasty atopic sclerokeratitis in keratoconus patients. Ophthalmology 2008;115:851-856.

89. Ozawa Y, Nakao K, Kurihara T, et al. Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. The Journal of biological chemistry 2008;283:24561-24570.

90. Mochimaru H, Usui T, Yaguchi T, et al. Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2. Invest Ophthalmol Vis Sci 2008;49:2172-2177.

91. Miyashita H, Shimmura S, Higa K, et al. A novel NIH/3T3 duplex feeder system to engineer corneal epithelial sheets with enhanced cytokeratin 15-positive progenitor populations. Tissue engineering 2008;14:1275-1282.

92. Kawakita T, Shimmura S, Hornia A, Higa K, Tseng SC. Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell. Journal of cellular and molecular medicine 2008;12:1303-1316.

93. Igarashi T, Shimmura S, Yoshida S, Tonogi M, Shinozaki N, Yamane GY. Isolation of oral epithelial progenitors using collagen IV. Oral diseases 2008;14:413-418.

94. Uchino Y, Shimmura S, Miyashita H, et al. Amniotic membrane immobilized poly(vinyl alcohol) hybrid polymer as an artificial cornea scaffold that supports a stratified and differentiated corneal epithelium. J Biomed Mater Res B Appl Biomater 2007;81:201-206.

95. Shimazaki J, Higa K, Morito F, et al. Factors influencing outcomes in cultivated limbal epithelial transplantation for chronic cicatricial ocular surface disorders. Am J Ophthalmol 2007;143:945-953.

96. Ozawa Y, Nakao K, Shimazaki T, et al. SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Developmental biology 2007;303:591-600.

97. Ogawa Y, Razzaque MS, Kameyama K, et al. Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD. Invest Ophthalmol Vis Sci 2007;48:1079-1086.

98. Miyashita H, Higa K, Kato N, et al. Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro. Invest Ophthalmol Vis Sci 2007;48:3586-3593.

99. Matsumoto Y, Dogru M, Sato EA, et al. The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. Mol Vis 2007;13:1319-1326.

100. Kato N, Shimmura S, Kawakita T, et al. Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci 2007;48:1511-1517.

101. Higuchi A, Ueno R, Shimmura S, Suematsu M, Dogru M, Tsubota K. Albumin rescues ocular epithelial cells from cell death in dry eye. Curr Eye Res 2007;32:83-88.

102. Higa K, Shimmura S, Kato N, et al. Proliferation and Differentiation of Transplantable Rabbit Epithelial Sheets Engineered with or without an Amniotic Membrane Carrier. Invest Ophthalmol Vis Sci 2007;48:597-604.

103. Dogru M, Kato N, Matsumoto Y, et al. Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Curr Eye Res 2007;32:863-870.

104. Den S, Shimmura S, Tsubota K, Shimazaki J. Impact of the descemet membrane perforation on surgical outcomes after deep lamellar keratoplasty. Am J Ophthalmol 2007;143:750-754.

105. Yoshida S, Shimmura S, Nagoshi N, et al. Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea. Stem cells (Dayton, Ohio) 2006;24:2714-2722.

106. Yoshida S, Shimmura S, Kawakita T, et al. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci 2006;47:4780-4786.

107. Uchino Y, Goto E, Takano Y, et al. Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency. Ophthalmology 2006;113:1098-1101.

108. Tomita M, Shimmura S, Tsubota K, Shimazaki J. Dacryoadenitis associated with Acanthamoeba keratitis. Arch Ophthalmol 2006;124:1239-1242.

109. Shimmura S, Miyashita H, Uchino Y, et al. Microkeratome assisted deep lamellar keratoprosthesis. Br J Ophthalmol 2006;90:826-829.

110. Shimmura S, Miyashita H, Higa K, Yoshida S, Shimazaki J, Tsubota K. Proteomic analysis of soluble factors secreted by limbal fibroblasts. Mol Vis 2006;12:478-484.

111. Shimazaki J, Konomi K, Shimmura S, Tsubota K. Ocular surface reconstruction for thermal burns caused by fireworks. Cornea 2006;25:139-145.

112. Miyashita H, Shimmura S, Kobayashi H, et al. Collagen-immobilized poly(vinyl alcohol) as an artificial cornea scaffold that supports a stratified corneal epithelium. J Biomed Mater Res B Appl Biomater 2006;76:56-63.

113. Maruyama-Hosoi F, Shimazaki J, Shimmura S, Tsubota K. Changes Observed in Keratolimbal Allograft. Cornea 2006;25:377-382.

114. Kawashima M, Kawakita T, Den S, Shimmura S, Tsubota K, Shimazaki J. Comparison of deep lamellar keratoplasty and penetrating keratoplasty for lattice and macular corneal dystrophies. Am J Ophthalmol 2006;142:304-309.

115. Higuchi A, Shimmura S, Takeuchi T, Suematsu M, Tsubota K. Elucidation of apoptosis induced by serum deprivation in cultured conjunctival epithelial cells. Br J Ophthalmol 2006;90:760-764.

116. Higa K, Shimmura S, Shimazaki J, Tsubota K. Ocular surface epithelial cells up-regulate HLA-G when expanded in vitro on amniotic membrane substrates. Cornea 2006;25:715-721.

117. Den S, Shimizu K, Ikeda T, Tsubota K, Shimmura S, Shimazaki J. Association between meibomian gland changes and aging, sex, or tear function. Cornea 2006;25:651-655.

118. Den S, Dogru M, Kato N, Tanaka Y, Shimmura S, Shimazaki J. Disseminated keratoconjunctival epitheliopathy in a patient with systemic lupus erythematosus. Br J Ophthalmol 2006;90:1068-1070.

119. Yoshida S, Shimmura S, Shimazaki J, Shinozaki N, Tsubota K. Serum-free spheroid culture of mouse corneal keratocytes. Invest Ophthalmol Vis Sci 2005;46:1653-1658.

120. Shimmura S, Shimazaki J, Omoto M, Teruya A, Ishioka M, Tsubota K. Deep lamellar keratoplasty (DLKP) in keratoconus patients using viscoadaptive viscoelastics. Cornea 2005;24:178-181.

121. Shimmura S, Omoto M, Den S, Bissen-Miyajima H, Tsubota K, Shimazaki J. Microkeratome-assisted phacoemulsification. J Cataract Refract Surg 2005;31:1699-1701.

122. Shimmura S, Miyashita H, Konomi K, et al. Transplantation of corneal endothelium with Descemet’s membrane using a hyroxyethyl methacrylate polymer as a carrier. Br J Ophthalmol 2005;89:134-137.

123. Higa K, Shimmura S, Shimazaki J, Tsubota K. Hyaluronic acid-CD44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma. Cornea 2005;24:206-212.

124. Higa K, Shimmura S, Miyashita H, Shimazaki J, Tsubota K. Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells. Exp Eye Res 2005;81:218-223.

125. Dogru M, Asano-Kato N, Tanaka M, et al. Ocular Surface and MUC5AC Alterations in Atopic Patients with Corneal Shield Ulcers. Curr Eye Res 2005;30:897-908.

126. Shimmura S, Tadano K, Tsubota K. UV dose-dependent caspase activation in a corneal epithelial cell line. Curr Eye Res 2004;28:85-92.

127. Shimmura S, Ando M, Ishioka M, Shimazaki J, Tsubota K. Same-size donor corneas for myopic keratoconus. Cornea 2004;23:345-349.

128. Shimazaki J, Shinozaki N, Shimmura S, Holland EJ, Tsubota K. Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation. Transplantation 2004;78:216-220.

129. Shimazaki J, Shimmura S, Tsubota K. Donor source affects the outcome of ocular surface reconstruction in chemical or thermal burns of the cornea. Ophthalmology 2004;111:38-44.

130. Konomi K, Shimazaki J, Shimmura S, Akabane N, Goto E, Tsubota K. Efficacy of core vitrectomy preceding triple corneal procedure. Br J Ophthalmol 2004;88:1023-1025.

131. Kobayashi H, Kato M, Taguchi T, et al. Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea Mater Sci Eng C 2004;24:729-735.

132. Dogru M, Kaderli B, Gelisken O, et al. Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus. Am J Ophthalmol 2004;138:381-388.

133. Bissen-Miyajima H, Nakamura K, Kaido M, Shimmura S, Tsubota K. Role of the endothelial pump in flap adhesion after laser in situ keratomileusis. J Cataract Refract Surg 2004;30:1989-1992.

134. Shimmura S, Ueno R, Matsumoto Y, et al. Albumin as a tear supplement in the treatment of severe dry eye. Br J Ophthalmol 2003;87:1279-1283.

135. Shimmura S, Shimazaki J, Tsubota K. Therapeutic deep lamellar keratoplasty for cornea perforation. Am J Ophthalmol 2003;135:896-897.

136. Shimmura S, Ohashi Y, Shiroma H, Shimazaki J, Tsubota K. Corneal opacity and cataract: triple procedure versus secondary approach. Cornea 2003;22:234-238.

137. Shimmura S, Igarashi R, Yaguchi H, Ohashi Y, Shimazaki J, Tsubota K. Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers. Am J Ophthalmol 2003;135:613-619.

138. Shimmura S, Doillon CJ, Griffith M, et al. Collagen-poly(N-isopropylacrylamide)-based membranes for corneal stroma scaffolds. Cornea 2003;22:S81-88.

139. Shimazaki J, Kosaka K, Shimmura S, Tsubota K. Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium. Ophthalmology 2003;110:119-124.

140. Mori A, Shimazaki J, Shimmura S, Fujishima H, Oguchi Y, Tsubota K. Disposable eyelid-warming device for the treatment of meibomian gland dysfunction. Jpn J Ophthalmol 2003;47:578-586.

141. Asano-Kato N, Toda I, Shimmura S, et al. Detection of neutrophils and possible involvement of interleukin-8 in diffuse lamellar keratitis after laser in situ keratomileusis. J Cataract Refract Surg 2003;29:1996-2000.

142. Tsubota K, Shimmura S, Shinozaki N, Holland EJ, Shimazaki J. Clinical application of living-related conjunctival-limbal allograft. Am J Ophthalmol 2002;133:134-135.

143. Takahashi H, Sakamoto A, Takahashi R, Ohmura T, Shimmura S, Ohara K. Free radicals in phacoemulsification and aspiration procedures. Arch Ophthalmol 2002;120:1348-1352.

144. Shimazaki J, Shimmura S, Tsubota K. Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy). Cornea 2002;21:177-180.

145. Shimazaki J, Shimmura S, Ishioka M, Tsubota K. Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty(1). Am J Ophthalmol 2002;134:159-165.

146. Shimazaki J, Aiba M, Goto E, Kato N, Shimmura S, Tsubota K. Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders. Ophthalmology 2002;109:1285-1290.

147. Higuchi A, Shimmura S, Ishii M, Aburatani H, Tsubota K. Serum- and serum deprivation-induced transcriptional profiles of cultured conjunctival epithelial cells. Adv Exp Med Biol 2002;506:673-676.

148. Goto E, Shimazaki J, Monden Y, et al. Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction. Ophthalmology 2002;109:2030-2035.

149. Goto E, Monden Y, Takano Y, et al. Treatment of non-inflamed obstructive meibomian gland dysfunction by an infrared warm compression device. Br J Ophthalmol 2002;86:1403-1407.

150. Shimmura S, Shimazaki J, Ohashi Y, Tsubota K. Anti-inflammatory effects of amniotic membrane transplantation in ocular surface disorders. Cornea 2001;20:408-413.

151. Shimazaki J, Maruyama F, Shimmura S, Fujishima H, Tsubota K. Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty. Cornea 2001;20:149-152.

152. Miyoshi T, Fukagawa K, Shimmura S, et al. Interleukin-8 concentrations in conjunctival epithelium brush cytology samples correlate with neutrophil, eosinophil infiltration, and corneal damage. Cornea 2001;20:743-747.

153. Ishioka M, Shimmura S, Yagi Y, Tsubota K. Pterygium and dry eye. Ophthalmologica 2001;215:209-211.

154. Hanada K, Shimazaki J, Shimmura S, Tsubota K. Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera. Am J Ophthalmol 2001;131:324-331.

155. Goto E, Shimmura S, Shimazaki J, Tsubota K. Treatment of superior limbic keratoconjunctivitis by application of autologous serum. Cornea 2001;20:807-810.

156. Shimmura S, Matsumoto K, Yaguchi H, et al. Acidic electrolyzed water in the disinfection of the ocular surface. Exp Eye Res 2000;70:1-6.

157. Shimmura S, Ishioka M, Hanada K, Shimazaki J, Tsubota K. Telomerase activity and p53 expression in pterygia. Invest Ophthalmol Vis Sci 2000;41:1364-1369.

158. Shimmura S, Ando M, Shimazaki J, Tsubota K. Complications with one-piece lamellar kerato-limbal grafts for simultaneous limbal and corneal pathologies. Cornea 2000;19:439-442.

159. Shimazaki S, Shimmura S, Fujishima H, Tsubota K. Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome. Ophthalmology 2000;107:1518-1523.

160. Shimazaki J, Hanada K, Yagi Y, et al. Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol v 0. 12% unoprostone. Br J Ophthalmol 2000;84:1250-1254.

161. Nakamura K, Bissen-Miyajima H, Shimmura S, Tsubota K. Clinical application of Er:YAG laser for the treatment of pterygium. Ophthalmic Surg Lasers 2000;31:8-12.

162. Ishioka M, Shimazaki J, Yamagami J, Fujishima H, Shimmura S, Tsubota K. Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. Br J Ophthalmol 2000;84:714-717.

163. Fukagawa K, Nakajima T, Saito H, et al. IL-4 induces eotaxin production in corneal keratocytes but not in epithelial cells. Int Arch Allergy Immunol 2000;121:144-150.

164. Tsubota K, Satake Y, Kaido M, et al. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. N Engl J Med 1999;340:1697-1703.

165. Tsubota K, Monden Y, Yagi Y, Goto E, Shimmura S. New treatement of dry eye. The effect of calcium ointment through eyelid skin delivery. Br J Ophthalmol 1999;83:767-770.

166. Tsubota K, Kaido M, Yagi Y, Fujihara T, Shimmura S. Diseases associated with ocular surface abnormalities: The importance of reflex tearing. Br J Ophthalmol 1999;83:89-91.

167. Tsubota K, Goto E, Shimmura S, Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology 1999;106:1984-1989.

168. Tsubota K, Goto E, Fujita H, et al. Treatment of dry eye by autologus serum application in Sjogren’s Syndrome. Br J Ophthalmol 1999;83:390-395.

169. Tsubota K, Fukagawa K, Fujihara T, et al. Regulation of HLA DR expression in human conjunctival epithelium. Invest Ophthalmol Vis Sci 1999;40:28-34.

170. Takano Y, Fukagawa K, Shimmura S, Tsubota K, Oguchi Y, Saito H. IL-4 regulates chemokine production induced by TNF-a in keratocytes and corneal epithelial cells. Br J Ophthalmol 1999;83:1074-1076.

171. Shimmura S, Shimazaki J, Tsubota K. Results of a population -based questionnaire on the symptoms and lifestyles associated with dry eye. Cornea 1999;18:408-411.

172. Shimmura S, Masumizu T, Urayama K, Shimazaki J, Bissen-Miyajima H, Tsubota K. Excimer laser-induced hydroxyl radical formation and keratocyte death in vitro. Invest Ophthalmol Vis Sci 1999;40:1245-1249.

173. Shimazaki J, Shimmura S, Yamato K, Tsubota K. Morphology and barrier function of the corneal epithelium following penetrating keratoplasty: association with original diseases, tear function, and suture removal. Cornea 1999;18:559-564.

174. Shimazaki J, Kaido M, Shinozaki N, et al. Evidence of long-term survival of donor-derived cells after limbal allograft transplantation. Invest Ophthalmol Vis Sci 1999;40:1664-1668.

175. Nakamura K, Bissen-Miyajima H, Arai H, et al. Iatrogenic cataract after laser-assisted in situ keratomileusis. Am J Ophthalmol 1999;128:507-509.

176. Fukagawa K, Nakajima T, Tsubota K, Shimmura S, Saito H, Hirai K. Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. J Allergy Clin Immunol 1999;103:1220-1221.

177. Bissen-Miyajima H, Shimmura S, Tsubota K. Thermal effect on corneal incisions with different ultrasonic tips. J Cataract Refract Surg 1999;25:60-64.

178. Shimmura S, Shinozaki N, Fukagawa K, Shimazaki J, Tsubota K. Real-time telemedicine in the clinical assessment of the ocular surface. Am J Ophthalmol 1998;125:388-390.

179. Shimmura S, Shimoyama M, Hojo M, Urayama K, Tsubota K. Reoxygenation injury in a cultured corneal epithelial cell line protected by the uptake of lactoferrin. Invest Ophthalmol Vis Sci 1998;39:1346-1351.

180. Shimmura S, Matsumoto K, Goto E, et al. Lecithin-bound superoxide dismutase in the prevention of neutrophil-induced damage of corneal tissue. Invest Ophthalmol Vis Sci 1998;39:30-35.

181. Shimmura S, Goto E, Shimazaki J, Tsubota K. Viscosity-dependent fluid dynamics of eyedrops on the ocular surface. Am J Ophthalmol 1998;125:386-388.

182. Shimazaki J, Yang H-Y, Shimmura S, Tsubota K. Terrien’s marginal degeneration associated with erythema elevatum diutinum. Cornea 1998;17:342-344.

183. Shimazaki J, Shimmura S, Tsubota K. Intraoperative versus postoperative suture adjustment after penetrating keratoplasty. Cornea 1998;17:590-594.

184. Shimazaki J, Goto E, Ono M, Shimmura S, Tsubota K. Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology 1998;105:1485-1488.

185. Shimoyama M, Shimmura S, Tsubota K, Oguchi Y. Suppression of nuclear factor kappa B and CD 18 mediated leukocyte adhesion to the corneal endothelium by dexamethasone. Invest Ophthalmol Vis Sci 1997;38:2427-2431.

186. Shimmura S, Yang H-Y, Bissen-Miyajima H, Shimazaki J, Tsubota K. Posterior corneal protrusion following PRK. Cornea 1997;16:686-688.

187. Shimmura S, Tsubota K. Ultraviolet B-induced mitochondrial dysfunction is associated with decreased cell detachment of corneal epithelial cells in vitro. Invest Ophthalmol Vis Sci 1997;38:620-626.

188. Shimmura S, Shinozaki N, Fukagawa K, Tsubota K. Telemedicine in the follow-up of corneal transplant patients. J Telemed Telecare 1997;3:227-228.

189. Fukagawa K, Saito H, Tsubota K, et al. RANTES production in a conjunctival epithelial cell line. Cornea 1997;16:564-570.

190. Shimmura S, Suematsu M, Shimoyama M, Tsubota K, Oguchi Y, Ishimura Y. Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells: the protective effects of lactoferrin. Exp Eye Res 1996;63:519-526.

191. Shimmura S, Ono M, Shinozaki K, et al. Sodium hyaluronate eyedrops in the treatment of dry eyes. Br J Ophthalmol 1995;79:1007-1011.

192. Shimmura S, Tsubota K, Oguchi Y, Fukumura D, Suematsu M, Tsuchiya M. Oxiradical-dependent photoemission induced by a phacoemulsification probe. Invest Ophthalmol Vis Sci 1992;33:2904-2907.